N-3 PUFA improved pup separation-induced postpartum depression via serotonergic pathway regulated by miRNA
DC Field | Value | Language |
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dc.contributor.author | Choi, Jeong-Eun | - |
dc.contributor.author | Kim, Eun-Young | - |
dc.contributor.author | Park, Yongsoon | - |
dc.date.accessioned | 2022-07-07T14:33:58Z | - |
dc.date.available | 2022-07-07T14:33:58Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2020-10 | - |
dc.identifier.issn | 0955-2863 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/144994 | - |
dc.description.abstract | Stress and ovarian hormone fluctuation are risk factors for postpartum depression (PPD). Previous studies suggested antidepressant-like effects of n-3 polyunsaturated fatty acids (PUFA), but their effect on dam animal with additional stress were not clear. The purpose of the present study was to investigate the hypothesis that n-3 PUFA improved PPD through the serotonergic and glutamatergic pathways by modulating miRNA. Rats were fed n-3 PUFA or control diet from gestation, with pup separation (PS) on postpartum days 2–14 and non-PS controls. N-3 PUFA reversed PS-induced depressive behaviors, including increased immobility, latencies to contact first pup and retrieve all pups, and decreased sucrose preference. N-3 PUFA also modulated the hypothalamic–pituitary–adrenal (HPA) axis by decreasing circulating levels of adrenocorticotropic hormone and corticosterone and expression of hypothalamic corticotrophin releasing factor and hippocampal miRNA-218 but increasing the hippocampal expression of glucocorticoid receptor. N-3 PUFA inhibited neuroinflammation by decreasing circulating levels of prostaglandin E2 and hippocampal expression of tumor necrosis factor-α, interleukin-6, and miRNA-155. In addition, n-3 PUFA up-regulated the serotonergic pathway by increasing circulating levels of serotonin and hippocampal expression of serotonin-1A receptor, cAMP response element binding protein (CREB), pCREB, brain-derived neurotrophic factor, and miRNA-182 but did not affect the glutamatergic pathway according to the hippocampal expression of N-methyl-D-aspartate receptor-2B. The present study suggested that n-3 PUFA improved PPD through the serotonergic pathway by modifying the HPA axis, neuroinflammation, and related miRNAs. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.title | N-3 PUFA improved pup separation-induced postpartum depression via serotonergic pathway regulated by miRNA | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Yongsoon | - |
dc.identifier.doi | 10.1016/j.jnutbio.2020.108417 | - |
dc.identifier.scopusid | 2-s2.0-85087313507 | - |
dc.identifier.wosid | 000580073700003 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NUTRITIONAL BIOCHEMISTRY, v.84, pp.1 - 10 | - |
dc.relation.isPartOf | JOURNAL OF NUTRITIONAL BIOCHEMISTRY | - |
dc.citation.title | JOURNAL OF NUTRITIONAL BIOCHEMISTRY | - |
dc.citation.volume | 84 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 10 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.subject.keywordPlus | POLYUNSATURATED FATTY-ACIDS | - |
dc.subject.keywordPlus | 17-BETA-ESTRADIOL INJECTION | - |
dc.subject.keywordPlus | MATERNAL SEPARATION | - |
dc.subject.keywordPlus | 5-HT1A RECEPTORS | - |
dc.subject.keywordPlus | RAT HIPPOCAMPUS | - |
dc.subject.keywordPlus | BEHAVIOR | - |
dc.subject.keywordPlus | ANXIETY | - |
dc.subject.keywordPlus | OMEGA-3-FATTY-ACIDS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | MOOD | - |
dc.subject.keywordAuthor | MiRNA | - |
dc.subject.keywordAuthor | N-3 PUFA | - |
dc.subject.keywordAuthor | NMDA receptor | - |
dc.subject.keywordAuthor | Postpartum depression | - |
dc.subject.keywordAuthor | Rats | - |
dc.subject.keywordAuthor | Serotonin | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0955286320304496?via%3Dihub | - |
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