N-3 PUFA improved pup separation-induced postpartum depression via serotonergic pathway regulated by miRNA
- Authors
- Choi, Jeong-Eun; Kim, Eun-Young; Park, Yongsoon
- Issue Date
- Oct-2020
- Publisher
- ELSEVIER SCIENCE INC
- Keywords
- MiRNA; N-3 PUFA; NMDA receptor; Postpartum depression; Rats; Serotonin
- Citation
- JOURNAL OF NUTRITIONAL BIOCHEMISTRY, v.84, pp.1 - 10
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF NUTRITIONAL BIOCHEMISTRY
- Volume
- 84
- Start Page
- 1
- End Page
- 10
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/144994
- DOI
- 10.1016/j.jnutbio.2020.108417
- ISSN
- 0955-2863
- Abstract
- Stress and ovarian hormone fluctuation are risk factors for postpartum depression (PPD). Previous studies suggested antidepressant-like effects of n-3 polyunsaturated fatty acids (PUFA), but their effect on dam animal with additional stress were not clear. The purpose of the present study was to investigate the hypothesis that n-3 PUFA improved PPD through the serotonergic and glutamatergic pathways by modulating miRNA. Rats were fed n-3 PUFA or control diet from gestation, with pup separation (PS) on postpartum days 2–14 and non-PS controls. N-3 PUFA reversed PS-induced depressive behaviors, including increased immobility, latencies to contact first pup and retrieve all pups, and decreased sucrose preference. N-3 PUFA also modulated the hypothalamic–pituitary–adrenal (HPA) axis by decreasing circulating levels of adrenocorticotropic hormone and corticosterone and expression of hypothalamic corticotrophin releasing factor and hippocampal miRNA-218 but increasing the hippocampal expression of glucocorticoid receptor. N-3 PUFA inhibited neuroinflammation by decreasing circulating levels of prostaglandin E2 and hippocampal expression of tumor necrosis factor-α, interleukin-6, and miRNA-155. In addition, n-3 PUFA up-regulated the serotonergic pathway by increasing circulating levels of serotonin and hippocampal expression of serotonin-1A receptor, cAMP response element binding protein (CREB), pCREB, brain-derived neurotrophic factor, and miRNA-182 but did not affect the glutamatergic pathway according to the hippocampal expression of N-methyl-D-aspartate receptor-2B. The present study suggested that n-3 PUFA improved PPD through the serotonergic pathway by modifying the HPA axis, neuroinflammation, and related miRNAs.
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