Expression of UTX Indicates Poor Prognosis in Patients With Luminal Breast Cancer and is Associated With MMP-11 Expression
- Authors
- Kim, Gi Jeong; Kim, Dong-Hoon; Min, Kyueng-Whan; Chae, Seoung Wan; Kim, Se Hoon; Son, Byoung Kwan; Moon, Kyoung Min; Kim, Young Hwan
- Issue Date
- Aug-2020
- Publisher
- LIPPINCOTT WILLIAMS & WILKINS
- Keywords
- breast cancer; UTX; MMP-11; prognosis; molecular classification
- Citation
- APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY, v.28, no.7, pp.544 - 550
- Indexed
- SCIE
SCOPUS
- Journal Title
- APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY
- Volume
- 28
- Number
- 7
- Start Page
- 544
- End Page
- 550
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/145309
- DOI
- 10.1097/PAI.0000000000000795
- ISSN
- 1541-2016
- Abstract
- Ubiquitously transcribed tetratricopeptide repeat, X chromosome (UTX) is involved in the epigenetic regulation. A previous mouse xenograft study revealed that UTX knockdown is associated with downregulated expression of matrix metalloproteinase-11 (MMP-11). The authors investigated 224 cases of breast cancer from Kangbuk Samsung Medical Center between 2000 and 2005. Nuclear UTX and cytoplasmic MMP-11 expressions were assessed using immunohistochemistry of tumor tissue microarray specimens. The relationships between the expression of UTX, MMP-11, and patients' outcomes were analyzed. UTX expression was significantly associated with high histologic grade, lymphatic invasion, vascular invasion, and tumoral expression of MMP-11. Survival analysis revealed that patients with UTX expression had a poorer overall survival rate (P=0.010) as well as diminished disease-free survival rate (P=0.001). The prognostic power of UTX expression was significant in patients with luminal-type breast cancer (P=0.027, overall survival;P=0.008, disease-free survival). Validation of UTX can provide further prognostic information beyond traditional indicators and represents a potential therapeutic target for breast cancer.
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