Serum Makorin ring finger protein 3 values for predicting Central precocious puberty in girls
- Authors
- Jeong, Hwal Rim; Lee, Hye Jin; Shim, Yeong Suk; Kang, Min Jae; Yang, Seung; Hwang, Il Tae
- Issue Date
- Aug-2019
- Publisher
- TAYLOR & FRANCIS LTD
- Keywords
- Precocious puberty; MKRN3; biomarker
- Citation
- GYNECOLOGICAL ENDOCRINOLOGY, v.35, no.8, pp.732 - 736
- Indexed
- SCIE
SCOPUS
- Journal Title
- GYNECOLOGICAL ENDOCRINOLOGY
- Volume
- 35
- Number
- 8
- Start Page
- 732
- End Page
- 736
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/147282
- DOI
- 10.1080/09513590.2019.1576615
- ISSN
- 0951-3590
- Abstract
- This study evaluated the serum level of MKRN3 and investigated its diagnostic usefulness in girls with central precocious puberty (CPP). In total, 41 girls with CPP and 35 age-matched normal control girls were enrolled. Serum values of MKRN3 were measured in both groups. Gonadotropin and estradiol concentrations were evaluated after 6 and 12 months of GnRH agonist (GnRHa) treatment in CPP patients. The MKRN3 concentrations were much lower in the patient group than in the control group (p = .005). Over 1 year of GnRHa treatment in patients, the gonadotropin concentrations were significantly decreased (p < .05), while the MKRN3 concentrations were unchanged (p > .05). MKRN3 levels were inversely correlated to standard deviation (SD) in height (r = −0.46, p = .000), SD in weight (r = −0.32, p = .005), Tanner stage (r = −0.41, p = .000), and bone age (r = −0.46, p = .000). Based on ROC analysis, the area under curve was 0.758 for MKRN3, with 82.9% sensitivity and 68.5% specificity. The measurement of serum MKRN3 level may provide some help for CPP prediction, but relatively various values need further validation
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