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Hybrid Nanofiber Scaffold-Based Direct Conversion of Neural Precursor Cells/Dopamine Neuronsopen access
- Authors
- Lim, Mi-Sun; Ko, Seung Hwan; Kim, Min Sung; Lee, Byungjun; Jung, Ho-Sup; Kim, Keesung; Park, Chang-Hwan
- Issue Date
- Jul-2019
- Publisher
- KOREAN SOC STEM CELL RESEARCH
- Keywords
- Hybrid nanofiber; Direct convcrsion; Neural precursor; iNPC
- Citation
- INTERNATIONAL JOURNAL OF STEM CELLS, v.12, no.2, pp.340 - 346
- Indexed
- SCIE
SCOPUS
- Journal Title
- INTERNATIONAL JOURNAL OF STEM CELLS
- Volume
- 12
- Number
- 2
- Start Page
- 340
- End Page
- 346
- ISSN
- 2005-3606
- Abstract
- The concept of cellular reprogramming was developed to generate induced neural precursor cells (iNPCs)/dopaminergic (iDA) neurons using diverse approaches. Here, we investigated the effects of various nanoscale scaffolds (fiber, dot, and line) on iNPC/iDA differentiation by direct reprogramming. The generation and maturation of iDA (microtubule-associated protein 2-positive and tyrosine hydroxylase-positive) and iNPCs (NESTIN-positive and SOX2-positive) increased on fiber and dot scaffolds as compared to that of the flat (control) scaffold. This study demon-strates that nanotopographical environments are suitable for direct differentiation methods and may improve the differentiation efficiency.
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Collections - 서울 의생명공학전문대학원 > 서울 의생명과학과 > 1. Journal Articles
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