Anti-aging potential of fish collagen hydrolysates subjected to simulated gastrointestinal digestion and Caco-2 cell permeationopen access
- Authors
- Hyun Jeong Je; Yoo Kyung Han; Hyeon Gyu Lee; In Young Bae
- Issue Date
- Mar-2019
- Publisher
- Korean Society for Applied Biological Chemistry
- Keywords
- Anti-aging peptide; Cellular permeability; Collagen synthesis Fish collagen hydrolysate; Matrix metalloproteinase-1 inhibition
- Citation
- Journal of Applied Biological Chemistry, v.62, no.1, pp.101 - 107
- Indexed
- SCOPUS
KCI
- Journal Title
- Journal of Applied Biological Chemistry
- Volume
- 62
- Number
- 1
- Start Page
- 101
- End Page
- 107
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/148173
- DOI
- 10.3839/jabc.2019.015
- ISSN
- 1976-0442
- Abstract
- The objectives of this study were to evaluate the antiaging effects and investigate the effect of simulated gastrointestinal (GI) digestion on the anti-aging properties and intestinal permeation of the potential fish collagen hydrolysates (FCH). Therefore, procollagen synthesis, matrix metalloproteinase-1 (MMP-1) production, and Caco-2 cell permeability were analyzed before and after in vitro digestion for FCHs, low-molecular weight fractions (<1 kDa), and high molecular weight fractions (>1 kDa). After being subjected to GI digestion, the level of MMP-1 inhibition was maintained, although the procollagen production was significantly (>20%) lower with all samples. Also, the digested FCHs and their <1 kDa fraction yielded 9.1 and 13.8% increased peptide transport, respectively, compared to undigested samples. Based on the effective intestinal permeation and high digestive enzyme stability, the <1 kDa fraction of FCHs is a potential bioactive material suitable for anti-aging applications in the food and cosmetics industries.
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