폐경 전후 한국 여성의 혈청 아연 농도와 골질량 및 골밀도의 상관성 : 2010 국민건강영양조사 자료에 근거하여

Abstract

Osteoporosis is a common and multi-factorial disease characterized by low bone mass and architectural deterioration of bone tissue. One of the important factors in the development of osteoporosis is nutrition, and several studies reported that Zinc is positively associated with mineralization of bone. The present study investigates the hypothesis that serum zinc levels are positively associated with bone mass in Korean postmenopausal women. This cross-sectional study was performed using data from the Korea National Health and Nutrition Examination Survey, 2010. Participants (n=615) were divided into a premenopausal (n=477) and postmenopausal (n=138) group. Both groups were subdivided into five groups according to quintiles of serum zinc levels. Multiple linear regression analysis was performed to assess relationships between serum zinc levels and bone mineral density or content (BMD or BMC). The results showed that high serum zinc levels were positively associated with BMD of total femur, BMC and BMD of femoral neck in postmenopausal women but not in premenopausal women. Additionally, high serum zinc levels were significantly associated with high BMC and BMD of femoral neck in postmenopausal women with osteoporosis. This study demonstrates that high serum zinc levels are positively associated with BMC and BMD of femoral neck in Korean postmenopausal women with osteoporosis, which suggested that high serum zinc levels could be a beneficial effect for bone health in postmenopausal women.