Associations of serum levels of vitamins A, C, and E with the risk of cognitive impairment among elderly Koreansopen access
- Authors
- Kim, Sung Hee; Park, Yeong Mi; Choi, Bo Youl; Kim, Mi Kyung; Roh, Sungwon; Kim, Kyunga; Yang, Yoon Jung
- Issue Date
- Apr-2018
- Publisher
- KOREAN NUTRITION SOC
- Keywords
- Dementia; cognition; vitamin A; ascorbic acid; vitamin E
- Citation
- NUTRITION RESEARCH AND PRACTICE, v.12, no.2, pp.72 - 77
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- NUTRITION RESEARCH AND PRACTICE
- Volume
- 12
- Number
- 2
- Start Page
- 72
- End Page
- 77
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/150265
- DOI
- 10.4162/nrp.2018.12.2.160
- ISSN
- 1976-1457
- Abstract
- BACKGROUND/OBJECTIVES
Korea is quickly becoming an aged society. Dementia is also becoming a vital public health problem in Korea. Cognitive impairment as a pre-stage of dementia shares most risk factors for dementia. The aim of the present study was to determine associations of serum levels of vitamins A, C, and E with the risk of cognitive impairment among elderly Koreans.
SUBJECTS/METHODS
In this cross-sectional study, a total of 230 participants aged 60–79 years from Yangpyeong cohort were included. Cognitive function was assessed by the Korean version of the Mini-Mental State Examination for Dementia Screening. The logistic multivariable regression model was applied to determine the effect of serum vitamins A, C, and E on the risk of cognitive impairment.
RESULTS
There was no significant association between the risk of cognitive impairment and serum levels of vitamin A and vitamin C. There was a significant odd ratio when the second tertile group of beta-gamma tocopherol level was compared to the first tertile group [odds ratio (OR) = 0.37, 95% confidence interval (CI) = 0.14–0.98, P for trend = 0.051]. In subgroup analyses, there were significant negative associations between beta-gamma tocopherol level and the risk of cognitive impairment in men (OR = 0.17, 95% CI = 0.03–0.87, P for trend = 0.028), non-drinkers or former drinkers (OR = 0.13, 95% CI = 0.02–0.66, P for trend = 0.025), and non-smokers or former smokers (OR = 0.27, 95% CI = 0.09–0.82, P for trend = 0.017).
CONCLUSION
Serum beta-gamma tocopherol levels tended to be inversely associated with the risk of cognitive impairment. Further prospective large-scaled studies are needed to examine this association.
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