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Interleukin-6-Mediated Induced Pluripotent Stem Cell (iPSC)-Derived Neural Differentiation
- Issue Date
- Apr-2018
- Publisher
- HUMANA PRESS INC
- Keywords
- BDNF; Brain; Interleukin-6; Neuron; Neurotrophin; STAT3
- Citation
- MOLECULAR NEUROBIOLOGY, v.55, no.4, pp.3513 - 3522
- Indexed
- SCIE
SCOPUS
- Journal Title
- MOLECULAR NEUROBIOLOGY
- Volume
- 55
- Number
- 4
- Start Page
- 3513
- End Page
- 3522
- ISSN
- 0893-7648
- Abstract
- In an aging society with an increasing threat to higher brain cognitive functions due to dementia, it becomes imperative to identify new molecular remedies for supporting adult neurogenesis. Interleukin-6 (IL-6) is a promising cytokine that can support neurogenesis under conditions of neurodegeneration, and neuron replacement is eventually possible due to its agonistic acting soluble receptor sIL-6R. Here, we report that activation of the IL-6-signal transducer and activator of transcription 3 (STAT3) axis is neurogenic and has potential therapeutic applications for the treatment of neurodegenerative diseases such as Parkinson's disease (PD).
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Related Researcher
- Jung, Sung Jun
- COLLEGE OF MEDICINE (DEPARTMENT OF PHYSIOLOGY)