Prognostic Implications of Postoperative Infectious Complications in Non-Small Cell Lung Canceropen access
- Authors
- Jang, Hyo Joon; Song, Jae Won; Cho, Sukki; Kim, Kwhanmien; Jheon, Sanghoon
- Issue Date
- Feb-2018
- Publisher
- 대한흉부외과학회
- Keywords
- Non-small-cell lung carcinoma; Complication; Prognosis
- Citation
- Korean Journal of Thoracic and Cardiovascular Surgery, v.51, no.1, pp.41 - 52
- Indexed
- SCOPUS
KCI
- Journal Title
- Korean Journal of Thoracic and Cardiovascular Surgery
- Volume
- 51
- Number
- 1
- Start Page
- 41
- End Page
- 52
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/150575
- DOI
- 10.5090/kjtcs.2018.51.1.41
- ISSN
- 2233-601X
- Abstract
- Background: Few studies have evaluated the long-term impact of postoperative infectious complications in patients with non-small cell lung cancer (NSCLC). We aimed to determine the impact of infectious complications on long-term outcomes after surgical resection for NSCLC. Methods: We performed a retrospective study of 1,380 eligible patients who underwent pulmonary resection for NSCLC from 2003 to 2012. Complications were divided into infectious complications and non-infectious complications. Kaplan-Meier survival analysis was used to compare unadjusted 5-year cancer-specific survival (CSS) rates and recurrence-free survival (RFS) rates. Cox regression was used to determine the impact of infectious complications on 5-year CSS and RFS. Results: The rate of total complications and infectious complications was 24.3% and 4.3%, respectively.
In the node-negative subgroup, the 5-year CSS and RFS rates were 75.9% and 57.1% in patients who had infectious complications, compared to 87.9% and 78.4% in patients who had no complications. Infectious complications were a negative prognostic factor for 5-year RFS (hazard ratio, 1.92; 95% confidence interval, 1.00–3.69; p=0.049). In the node-positive subgroup, the 5-year CSS rate and RFS were 44.6% and 48.4% in patients who had infectious complications, compared to 70.5% and 48.4% for patients who had no complications. Conclusion: Postoperative infectious complications had a negative impact on CSS and RFS in node-negative NSCLC. Our findings may help improve risk assessment for tumor recurrence after pulmonary resection for node-negative NSCLC.
- Files in This Item
-
- Appears in
Collections - 서울 의과대학 > 서울 흉부외과학교실 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/150575)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.