Longitudinal cortical thinning and cognitive decline in patients with early- versus late-stage subcortical vascular mild cognitive impairment
- Authors
- Lee, J.; Seo, S. W.; Yang, J. -J.; Jang, Y. K.; Lee, J. S.; Kim, Y. J.; Chin, J.; Lee, Jong Min; Kim, S. T.; Lee, K. -H.; Lee, J. H.; Kim, J. S.; Kim, S.; Yoo, H.; Lee, A. Y.; Na, D. L.; Kim, H. J.
- Issue Date
- Feb-2018
- Publisher
- WILEY
- Keywords
- cognition; cortical thickness; early stage; late stage; subcortical vascular mild cognitive impairment
- Citation
- EUROPEAN JOURNAL OF NEUROLOGY, v.25, no.2, pp.326 - 333
- Indexed
- SCIE
SCOPUS
- Journal Title
- EUROPEAN JOURNAL OF NEUROLOGY
- Volume
- 25
- Number
- 2
- Start Page
- 326
- End Page
- 333
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/150615
- DOI
- 10.1111/ene.13500
- ISSN
- 1351-5101
- Abstract
- Background and purposeBiomarker changes in cognitively impaired patients with small vessel disease are largely unknown. The rate of amyloid/lacune progression, cortical thinning and cognitive decline were evaluated in subcortical vascular mild cognitive impairment (svMCI) patients. MethodsSeventy-two svMCI patients were divided into early stage (ES-svMCI, n = 39) and late stage (LS-svMCI, n = 33) according to their Clinical Dementia Rating Sum of Boxes score. Patients were annually followed up with neuropsychological tests and brain magnetic resonance imaging for 3 years, and underwent a second [C-11] Pittsburgh compound B (PiB) positron emission tomography scan within a mean interval of 32.4 months. ResultsThere was no difference in the rate of increase in PiB uptake or lacune number between the ES-svMCI and LS-svMCI. However, LS-svMCI showed more rapid cortical thinning and cognitive decline than did the ES-svMCI. ConclusionsWe suggest that, whilst the rate of change in pathological burden did not differ between ES-svMCI and LS-svMCI, cortical thinning and cognitive decline progressed more rapidly in the LS-svMCI.
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