Optical Coherence Tomography Protocols for Screening of Hydroxychloroquine Retinopathy in Asian Patients
- Authors
- Ahn, Seong Joon; Joung, Jooyoung; Lim, Han Woong; Lee, Byung Ro
- Issue Date
- Dec-2017
- Publisher
- ELSEVIER SCIENCE INC
- Citation
- AMERICAN JOURNAL OF OPHTHALMOLOGY, v.184, pp.11 - 18
- Indexed
- SCIE
SCOPUS
- Journal Title
- AMERICAN JOURNAL OF OPHTHALMOLOGY
- Volume
- 184
- Start Page
- 11
- End Page
- 18
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/151063
- DOI
- 10.1016/j.ajo.2017.09.025
- ISSN
- 0002-9394
- Abstract
- Purpose
To investigate the distribution of outer retinal changes in hydroxychloroquine (HCQ) retinopathy and explore optical coherence tomography (OCT) protocols to maximize the sensitivity of HCQ retinopathy detection in Asian patients.
Design
Diagnostic validity assessment.
Methods
Setting: Institutional. Patient Population: Forty-eight eyes (24 patients) with HCQ retinopathy underwent 6-mm horizontal and vertical line scans and 6 × 6-mm2 volume scans using spectral-domain OCT (SD-OCT), and 9-mm line scans and 6 × 6-mm2 and 12 × 9-mm2 volume scans using swept-source OCT (SS-OCT). Observation Procedures: Distances from the fovea to the defective photoreceptors were measured in the temporal, nasal, superior, and inferior directions from line scan OCT images. The sensitivity of retinopathy detection, indicated by photoreceptor defects, was compared among protocols. Main Outcome Measures: Detection of photoreceptor defects and distances from the fovea to the defects.
Results
The average minimum distance from the fovea to an area of photoreceptor defects was 1.84 ± 1.26 mm (mean ± standard deviation). The distances were greater than 3 mm horizontally and vertically in 15 (31.3%) and 17 (35.4%) eyes with HCQ retinopathy, respectively, and only wide-field line or volume scans could detect defects in the eyes. The 9-mm line scans detected HCQ retinopathy significantly better than 6-mm scans (P < .001); the sensitivity of the wide volume scan was significantly greater than the standard volume scan (P = .001). The 12 × 9-mm2 volume scan detected retinopathy with the greatest sensitivity (100%).
Conclusions
Our study recommends a wide-field OCT scan to screen Asian patients taking HCQ medications.
- Files in This Item
-
Go to Link
- Appears in
Collections - 서울 의과대학 > 서울 안과학교실 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/151063)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.