Functional repertoire of interleukin-6 in the central nervous system - a review
- Authors
- Heese, Klaus
- Issue Date
- Nov-2017
- Publisher
- IOS PRESS
- Keywords
- Brain; IL-6; neural stem cell; neurogenesis; neuron; signaling; synapse
- Citation
- RESTORATIVE NEUROLOGY AND NEUROSCIENCE, v.35, no.6, pp.693 - 701
- Indexed
- SCIE
SCOPUS
- Journal Title
- RESTORATIVE NEUROLOGY AND NEUROSCIENCE
- Volume
- 35
- Number
- 6
- Start Page
- 693
- End Page
- 701
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/151226
- DOI
- 10.3233/RNN-170772
- ISSN
- 0922-6028
- Abstract
- In an aging society with dementia imposing an increasing threat to higher brain cognitive functions, understanding the molecular and cellular events of adult neurogenesis is imperative. Interleukin-6 (IL-6), along with its agonistic acting soluble receptor sIL-6R (the combined proteins are also known as Hyper-IL-6), is a promising cytokine that can support neurogenesis under conditions of neurodegeneration when neuron replacement is needed. In contrast to the previously reported gliogenic effects of activation of the IL-6-signal transducer and activator of transcription 3 (STAT3) axis, this review summarizes recent studies showing that IL-6 activation can be neurogenic and has potential therapeutic applications for the treatment of neurodegenerative diseases such as Parkinson's disease.
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