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Zika virus directly infects peripheral neurons and induces cell deathopen access
- Authors
- Oh, Yohan; Zhang, Feiran; Wang, Yaqing; Lee, Emily M.; Choi, In Young; Lim, Hotae; Mirakhori, Fahimeh; Li, Ronghua; Huang, Luoxiu; Xu, Tianlei; Wu, Hao; Li, Cui; Qin, Cheng-Feng; Wen, Zhexing; Wu, Qing-Feng; Tang, Hengli; Xu, Zhiheng; Jin, Peng; Song, Hongjun; Ming, Guo-li; Lee, Gabsang
- Issue Date
- Sep-2017
- Publisher
- NATURE RESEARCH
- Citation
- NATURE NEUROSCIENCE, v.20, no.9, pp.1209 - 1212
- Indexed
- SCIE
SCOPUS
- Journal Title
- NATURE NEUROSCIENCE
- Volume
- 20
- Number
- 9
- Start Page
- 1209
- End Page
- 1212
- ISSN
- 1097-6256
- Abstract
- Zika virus (ZIKV) infection is associated with neurological disorders of both the CNS and peripheral nervous systems (PNS), yet few studies have directly examined PNS infection. Here we show that intraperitoneally or intraventricularly injected ZIKV in the mouse can infect and impact peripheral neurons in vivo. Moreover, ZIKV productively infects stemcell- derived human neural crest cells and peripheral neurons in vitro, leading to increased cell death, transcriptional dysregulation and cell-type-specific molecular pathology.
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Collections - 서울 의생명공학전문대학원 > 서울 의생명과학과 > 1. Journal Articles
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