Development of efficient adeno-associated virus (AAV)-mediated gene delivery system with a phytoactive material for targeting human melanoma cells
- Authors
- Lee, John Hwan; Kim, Yoojin; Yoon, Ye-Eun; Kim, Yong-Jin; Oh, Seong-Geun; Jang, Jae-Hyung; Kim, Eunmi
- Issue Date
- Jul-2017
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- Adeno-associated virus; Pro-apoptotic gene; Gene delivery system; Melanoma; [6]-Gingerol
- Citation
- NEW BIOTECHNOLOGY, v.37, pp.194 - 199
- Indexed
- SCIE
SCOPUS
- Journal Title
- NEW BIOTECHNOLOGY
- Volume
- 37
- Start Page
- 194
- End Page
- 199
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/152065
- DOI
- 10.1016/j.nbt.2017.02.001
- ISSN
- 1871-6784
- Abstract
- We exploited the emerging potential of gene therapy strategies to design a powerful therapeutic system that combines two key components AAV vector and [6]-gingerol. In this study, we created an AAV2 construct expressing the proapoptotic protein BIM, which uses HSPG as its primary receptor, to target HSPG-overexpressing melanoma cells. This combination treatment showed promising results in vitro, inducing apoptosis in human melanoma cells. This new platform technology will make a significant contribution to numerous therapeutic applications, most notably for melanoma, including overcoming resistance to conventional anticancer therapies.
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