Correlations between Tumor to Background Ratio on Breast-Specific Gamma Imaging and Prognostic Factors in Breast Canceropen access
- Authors
- Lee, Soo Jin; Choi, Yun Young; Kim, Chanwoo; Chung, Min Sung
- Issue Date
- Jun-2017
- Publisher
- KOREAN ACAD MEDICAL SCIENCES
- Keywords
- Breast Cancer; Gamma Camera Imaging; Tc-99m-sestaMIBI
- Citation
- JOURNAL OF KOREAN MEDICAL SCIENCE, v.32, no.6, pp.1031 - 1037
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- JOURNAL OF KOREAN MEDICAL SCIENCE
- Volume
- 32
- Number
- 6
- Start Page
- 1031
- End Page
- 1037
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/152235
- DOI
- 10.3346/jkms.2017.32.6.1031
- ISSN
- 1011-8934
- Abstract
- The purpose of this study was to investigate the correlations between tumor-to-background ratio (TBR) obtained from breast-specific gamma imaging (BSGI) and the prognostic factors of breast cancer. Sixty-seven patients with invasive ductal carcinoma who underwent preoperative BSGI were enrolled. The BSGI images were visually scored from 1 to 5 according to a breast imaging reporting and data system (BIRADS). The TBR results obtained from positive BSGI images were compared according to the following prognostic factors: tumor size; axillary lymph node metastasis; nuclear grade (NG); histologic grade (HG); subtype; Ki-67; and the expression profile of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). Among 67 images, 60 were classified as a positive finding (sensitivity 89.6%). A higher TBR value was significantly correlated with tumor size ≥ 2 cm (P = 0.001), axillary lymph node metastasis (P = 0.007), high HG (P = 0.029), negative PR status (P = 0.036), and Ki-67 ≥ 14% (P = 0.007). The TBR showed a significant difference between the luminal A and non-luminal A subtypes (P = 0.007). On multivariate analysis, TBR had a high correlation with tumor size ≥ 2 cm, axillary lymph node metastasis, and negative PR status (P = 0.003, 0.048, and 0.030, respectively). A high TBR on BSGI was significantly correlated with poor prognostic factors of breast cancer. Luminal A subtype, a breast cancer subtype with more favorable prognosis, was associated with a low TBR on BSGI.
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