Differential Progression of Midbrain Atrophy in Parkinsonism: Longitudinal MRI Study
- Authors
- Hwang, Minho; Yang, Hyunwoo; Kim, Younsoo; Youn, Jinyoung; Park, Jongkyu; Huh, Young Eun; Kim, Hee-Tae; Cho, Jin Whan
- Issue Date
- 2017
- Publisher
- KARGER
- Keywords
- Progressive supranuclear palsy-parkinsonism; Richardson' s syndrome; Longitudinal magnetic resonance imaging; Midbrain atrophy
- Citation
- NEURODEGENERATIVE DISEASES, v.17, no.1, pp.31 - 37
- Indexed
- SCIE
SCOPUS
- Journal Title
- NEURODEGENERATIVE DISEASES
- Volume
- 17
- Number
- 1
- Start Page
- 31
- End Page
- 37
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/153241
- DOI
- 10.1159/000448174
- ISSN
- 1660-2854
- Abstract
- Aims: To elucidate different patterns of progression of midbrain atrophy in patients with Richardson's syndrome (RS), progressive supranuclear palsy-parkinsonism (PSP-P), and Parkinson's disease (PD) using magnetic resonance imaging (MRI)-based visual rating indexes. Methods: We recruited 12 patients with PSP-RS, 12 with PSP-P, and 23 with PD for whom MRIs had been followed up for at least 2 years (mean +/- SD, 4.9 +/- 1.6 years) after the initial MRI. MRI-based visual rating indexes were used to estimate midbrain atrophy, including the ratio of the pontine to midbrain tegmental areas (P/M ratio) on a midsagittal image, the length between the interpeduncular fossa and the center of the cerebral aqueduct at the midmammillary-body level (M-TEGM) on axial images, and the morning glory sign. Results: Initially, there were no differences in MRI-based visual rating indexes between PSP-P and PD, while PSP-RS showed a higher P/M ratio and lower M-TEGM compared with PSP-P and PD. In PD, the P/M ratio and M-TEGM remained stable with disease progression. However, the extent of changes between initial and follow-up indexes was similarly greater for both PSP-RS and PSP-P than for PD. Finally, PSP-P showed a higher P/M ratio and lower M-TEGM compared with PD in the follow-up, while PSP-RS still exhibited the most profound changes. Conclusions: Midbrain atrophy progresses differentially in patients with PSP-RS, PSP-P, and PD. Longitudinal measurements of midbrain atrophy using MRI-based visual rating indexes can help distinguish patients with PSP-P from those with PSP-RS and PD.
- Files in This Item
-
Go to Link
- Appears in
Collections - 서울 의과대학 > 서울 신경과학교실 > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.