Roles and epigenetic regulation of epithelial-mesenchymal transition and its transcription factors in cancer initiation and progression
- Authors
- Lee, Jeong-Yeon; Kong, Gu
- Issue Date
- Dec-2016
- Publisher
- SPRINGER BASEL AG
- Keywords
- EMT; EMT transcription factor; Human cancer; Epigenetics; Chromatin; Histone modification; DNA methylation
- Citation
- CELLULAR AND MOLECULAR LIFE SCIENCES, v.73, no.24, pp.4643 - 4660
- Indexed
- SCIE
SCOPUS
- Journal Title
- CELLULAR AND MOLECULAR LIFE SCIENCES
- Volume
- 73
- Number
- 24
- Start Page
- 4643
- End Page
- 4660
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/153414
- DOI
- 10.1007/s00018-016-2313-z
- ISSN
- 1420-682X
- Abstract
- The epithelial-mesenchymal transition (EMT) is a crucial developmental process by which epithelial cells undergo a mesenchymal phenotypic change. During EMT, epigenetic mechanisms including DNA methylation and histone modifications are involved in the regulation of EMT-related genes. The epigenetic gene silencing of the epithelial marker E-cadherin has been well characterized. In particular, three major transcriptional repressors of E-cadherin, Snail, ZEB, and Twist families, also known as EMT-inducing transcription factors (EMT-TFs), play a crucial role in this process by cooperating with multiple epigenetic modifiers. Furthermore, recent studies have identified the novel epigenetic modifiers that control the expression of EMT-TFs, and these modifiers have emerged as critical regulators of cancer development and as novel therapeutic targets for human cancer. In this review, the diverse functions of EMT-TFs in cancer progression, the cooperative mechanisms of EMT-TFs with epigenetic modifiers, and epigenetic regulatory roles for the expression of EMT-TFs will be discussed.
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