A Comparison of Substantia Nigra T1 Hyperintensity in Parkinson's Disease Dementia, Alzheimer's Disease and Age-Matched Controls: Volumetric Analysis of Neuromelanin Imagingopen access
- Authors
- Moon, Won-Jin; Park, Ju-Yeon; Yun, Won-Sung; Jeon, Ji Yeong; Moon, Yeon Sil; Kim, Heejin; Kwak, Ki-Chang; Lee, Jong Min; Han, Seol-Heui
- Issue Date
- Sep-2016
- Publisher
- KOREAN RADIOLOGICAL SOC
- Keywords
- Neuromelanin; High-resolution T1-weighted imaging; Magnetic resonance; Parkinsonian disorders; Dementia; Alzheimer disease; Substantia nigra
- Citation
- KOREAN JOURNAL OF RADIOLOGY, v.17, no.5, pp.633 - 640
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- KOREAN JOURNAL OF RADIOLOGY
- Volume
- 17
- Number
- 5
- Start Page
- 633
- End Page
- 640
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/154004
- DOI
- 10.3348/kjr.2016.17.5.633
- ISSN
- 1229-6929
- Abstract
- Objective: Neuromelanin loss of substantia nigra (SN) can be visualized as a T1 signal reduction on T1-weighted high-resolution imaging. We investigated whether volumetric analysis of T1 hyperintensity for SN could be used to differentiate between Parkinson's disease dementia (PDD), Alzheimer's disease (AD) and age-matched controls. Materials and Methods: This retrospective study enrolled 10 patients with PDD, 18 patients with AD, and 13 age-matched healthy elderly controls. MR imaging was performed at 3 tesla. To measure the T1 hyperintense area of SN, we obtained an axial thin section high-resolution T1-weighted fast spin echo sequence. The volumes of interest for the T1 hyperintense SN were drawn onto heavily T1-weighted FSE sequences through midbrain level, using the MIPAV software. The measurement differences were tested using the Kruskal-Wallis test followed by a post hoc comparison. Results: A comparison of the three groups showed significant differences in terms of volume of T1 hyperintensity (p < 0.001, Bonferroni corrected). The volume of T1 hyperintensity was significantly lower in PDD than in AD and normal controls (p < 0.005, Bonferroni corrected). However, the volume of T1 hyperintensity was not different between AD and normal controls (p = 0.136, Bonferroni corrected). Conclusion: The volumetric measurement of the T1 hyperintensity of SN can be an imaging marker for evaluating neuromelanin loss in neurodegenerative diseases and a differential in PDD and AD cases.
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