Diagnostic Value of the Serum Anti-Toxocara IgG Titer for Ocular Toxocariasis in Patients with Uveitis at a Tertiary Hospital in Korea.open access
- Authors
- Bae, Ki Woong; Ahn, Seong Joon; Park, Kyu Hyung; Woo, Se Joon
- Issue Date
- Aug-2016
- Publisher
- 대한안과학회
- Keywords
- Enzyme-linked immunosorbent assay; Toxocariasis; Uveitis
- Citation
- KOREAN JOURNAL OF OPHTHALMOLOGY, v.30, no.4, pp.258 - 264
- Indexed
- SCOPUS
KCI
- Journal Title
- KOREAN JOURNAL OF OPHTHALMOLOGY
- Volume
- 30
- Number
- 4
- Start Page
- 258
- End Page
- 264
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/154120
- DOI
- 10.3341/kjo.2016.30.4.258
- ISSN
- 1011-8942
- Abstract
- Purpose
This study evaluated the prevalence of ocular toxocariasis (OT) in patients with uveitis of unknown etiology who visited a tertiary hospital in South Korea and assessed the success of serum anti-Toxocara immunoglobulin G (IgG) enzyme-linked immunosorbent assay (ELISA) as a diagnostic test for OT.
Methods
The records of consecutive patients with intraocular inflammation of unknown etiology were reviewed. All participants underwent clinical and laboratory investigations, including ELISA for serum anti-Toxocara IgG. OT was diagnosed based on typical clinical findings. Clinical characteristics, seropositivity, and IgG titers were compared between patients diagnosed with OT and non-OT uveitis. The seropositivity and the diagnostic value of anti-Toxocara IgG was investigated among patients with different types of uveitis.
Results
Of 238 patients with uveitis of unknown etiology, 71 (29.8%) were diagnosed with OT, and 80 (33.6%) had positive ELISA results for serum anti-Toxocara IgG. The sensitivity and specificity of the ELISA test were 91.5% (65 / 71) and 91.0% (152 / 167), respectively. The positive predictive value of the serum anti-Toxocara IgG assay was 81.3%. Among patients with anterior, intermediate, posterior, and panuveitis, the prevalence rates of OT were 8.3%, 47.1%, 44.8%, and 7.1%, respectively; the seropositivity percentages were 18.1%, 47.1%, 43.7%, and 17.9%; and the positive predictive values were 38.5%, 95.8%, 92.1%, and 40.0%. The serum anti-Toxocara IgG titer also significantly decreased following albendazole treatment.
Conclusions
OT is a common cause of intraocular inflammation in the tertiary hospital setting. Considering that OT is more prevalent in intermediate and posterior uveitis, and that the positive predictive value of the anti-Toxocara IgG assay is high, a routine test for anti-Toxocara IgG might be necessary for Korean patients with intermediate and posterior uveitis.
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