Chitosan/poly-γ-glutamic acid nanoparticles improve the solubility of lutein
- Authors
- Hong, Da Young; Lee, Ji-Soo; Lee, Hyeon Gyu
- Issue Date
- Apr-2016
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- Lutein; Nanoparticle; Solubility
- Citation
- INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, v.85, pp.9 - 15
- Indexed
- SCIE
SCOPUS
- Journal Title
- INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
- Volume
- 85
- Start Page
- 9
- End Page
- 15
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/154852
- DOI
- 10.1016/j.ijbiomac.2015.12.044
- ISSN
- 0141-8130
- Abstract
- The aim of this study was to improve the solubility of lutein through the use of chitosan (CS)/poly-γ-glutamic acid (γ-PGA) nanoencapsulation. In terms of redispersibility, water-soluble chitosan (WsCS)/γ-PGA nanoparticles (NPs) were better than insoluble chitosan (InCS)/γ-PGA NPs. The lutein-loaded WsCS/γ-PGA NP has a spherical form with a size around 200 nm and a narrow size distribution (PDI < 0.1). Solubility measures showed that nanoencapsulation of lutein into WsCS/γ-PGA NPs resulted in a significant 12-fold higher solubility compared to that of non-nanoencapsulated lutein (p < 0.05). The redispersibility index of the lutein-loaded NPs was 1.01, indicating that they were completely reconstituted into aqueous solution as same as original aqueous solution. These results suggest that WsCS/γ-PGA nanoencapsulation can be used to enhance the solubility of lutein and other poorly water-soluble compounds.
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Collections - 서울 생활과학대학 > 서울 식품영양학과 > 1. Journal Articles
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