Controlling molecular orientations of hydrogels in oil-drug@hydrogel particle delivery systems for pH-selective/sustained release and stabilization of bioactive drugs
- Authors
- Song, Ji Eun; Lim, Sora; Kim, Do-Hoon; Cho, Eun Chul
- Issue Date
- Feb-2016
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- Oil-drug@hydrogel shell particles; Molecular orientation and crystallization of hydrogel; pH-selective and sustained drug releases; Anti-denaturation
- Citation
- COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, v.490, pp.49 - 58
- Indexed
- SCIE
SCOPUS
- Journal Title
- COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
- Volume
- 490
- Start Page
- 49
- End Page
- 58
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/155186
- DOI
- 10.1016/j.colsurfa.2015.11.032
- ISSN
- 0927-7757
- Abstract
- As potential oral and topical drug delivery applications, we fabricate oil-drug@molecularly-oriented hydrogel shells particles with regulated molecular orientation, for improved loading efficiencies, controlled and pH-specific releases, and anti-denaturation of hydrophilic drugs. The hydrogel shell is made with a natural polymer (alginate or curdlan) and Ca2+, and features oriented/crystallized structures. With a simple drop-dripping device, an optimum condition is established to encapsulate an oil-hydrophilic drug mixture with these shells and to manipulate molecular orientation/crystal structures of hydrogel shells. As a result, drug (arbutin) loading efficiencies are increased to 90% in the particles. In addition, depending on the types of physicochemical properties of hydrogel shells, not only pH-selective (in simulated gastric or intestinal fluid) but also pH-insensitive drug releases of oil-drug@hydrogel particles are possible. Moreover, due to crystals' excellent barrier properties, highly oriented hydrogels are also effective in preventing the denaturation of L-ascorbic acid, enabling long-lasting therapeutic effects of drug. This particulate system can also load a variety of functional materials in oil core of the core-shell particles and hence could expand the application to various fields.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 서울 공과대학 > 서울 화학공학과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/155186)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.