Alanine aminotransferase and gamma-glutamyl transferase have different dose-response relationships with risk of mortality by age
- Authors
- Oh, Chang-Mo; Won, Young-Joo; Cho, Hyunsoon; Lee, Jong-Keun; Park, Bo young; Jun, Jae Kwan; Koh, Dong-Hee; Ki, Moran; Jung, Kyu-Won; Oh, In-Hwan
- Issue Date
- Jan-2016
- Publisher
- Blackwell Publishing Inc.
- Keywords
- Age groups; Alanine aminotransferase; Cause of death; Gamma; Glutamyl transferase; Korea; Mortality
- Citation
- Liver International, v.36, no.1, pp.126 - 135
- Indexed
- SCIE
SCOPUS
- Journal Title
- Liver International
- Volume
- 36
- Number
- 1
- Start Page
- 126
- End Page
- 135
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/155254
- DOI
- 10.1111/liv.12879
- ISSN
- 1478-3223
- Abstract
- Background & Aims
It remains unclear whether the respective dose-response relationships between serum alanine aminotransferase (ALT) and gamma-glutamyl transferase (GGT) levels and risk of mortality are consistent by age.
Methods
We used sampled cohort data from the National Health Insurance Corporation to conduct a retrospective cohort study. A total of 313 252 participants who received medical health check-ups from 2002 to 2008 were assessed for risk of death according to serum ALT and GGT levels over an average of 6 years. The hazard ratios (HRs) for mortality were analysed with Cox proportional hazard model.
Results
The crude mortality rate increased linearly with increasing serum ALT and GGT levels in adults aged <60 years. However, the all-cause mortality rate showed a J-shaped relationship with increasing serum ALT levels whereas all-cause mortality rate showed a linear relationship with increasing serum GGT levels in adults aged ≥60 years. The HR of death showed U-shaped relationships with increasing serum ALT levels in adults aged ≥60 years. On the contrary, the HR of death from any cause had a linear association with increasing serum GGT levels among all age groups.
Conclusions
In this study, U-shaped relationship patterns were demonstrated between serum ALT levels and risk for all-cause mortality in adults aged ≥60 years while serum GGT levels showed a linear relationship with risk for all-cause death. Very low levels of serum ALT in elderly patients suggest that they are at high risk of mortality.
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