Prognostic Significance of 1-Year Serum Albumin Levels Within the Normal Range After Kidney Transplantation
- Authors
- Oh, Il Hwan; Park, Joon-Sung; Lee, Chang Hwa; Kang, Chong Myung; Kim, Gheun-Ho
- Issue Date
- Nov-2015
- Publisher
- WILEY
- Keywords
- Albumin; Kidney transplantation; Allograft survival; Patient survival; Cardiovascular mortality
- Citation
- ARTIFICIAL ORGANS, v.39, no.11, pp.965 - 972
- Indexed
- SCIE
SCOPUS
- Journal Title
- ARTIFICIAL ORGANS
- Volume
- 39
- Number
- 11
- Start Page
- 965
- End Page
- 972
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/155993
- DOI
- 10.1111/aor.12473
- ISSN
- 0160-564X
- Abstract
- Hypoalbuminemia is associated with poor outcomes in kidney transplantation (KT). However, what level is optimal in serum albumin is not clear for the long-term prognosis. To determine whether the long-term outcomes are different even between the normal ranges of serum albumin after KT, we analyzed data from 404 renal allograft recipients whose 1-year post-transplant serum albumin levels were within the normal limits (3.5-5.5g/dL). During a follow-up of 122 +/- 56 months, 97 graft losses, 20 patient deaths, and 50 cardiovascular (CV) events occurred. Based on 1-year serum albumin levels, the patients were divided into high normal (4.6g/dL, n=209) and low normal (<4.6g/dL, n=195) groups. Kaplan-Meier analyses revealed that the low normal group had poorer allograft survival (P=0.01), patient survival (P<0.001), and CV event-free survival (P<0.001) than the high normal group. Cox regression analysis confirmed that 1-year serum albumin was inversely associated with the risk of graft loss (hazard ratio [HR] 0.414, 95% confidence interval [CI] 0.200-0.856), patient death (HR 0.097, 95% CI 0.019-0.484), and CV events (HR 0.228, 95% CI 0.074-0.702). In conclusion, a relatively low 1-year post-transplant serum albumin level within the normal limits (<4.6g/dL) significantly predicts poor long-term outcomes.
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