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Dexamethasone-Conjugated Polyamidoamine Dendrimer for Delivery of the Heme Oxygenase-1 Gene into the Ischemic Brain
- Authors
- Jeon, Pureum; Choi, Manbok; Oh, Jungju; Lee, Minhyung
- Issue Date
- Jul-2015
- Publisher
- WILEY-V C H VERLAG GMBH
- Keywords
- dexamethasone; gene therapy; heme oxygenase-1; polyamidoamine; stroke
- Citation
- MACROMOLECULAR BIOSCIENCE, v.15, no.7, pp.1021 - 1028
- Indexed
- SCIE
SCOPUS
- Journal Title
- MACROMOLECULAR BIOSCIENCE
- Volume
- 15
- Number
- 7
- Start Page
- 1021
- End Page
- 1028
- ISSN
- 1616-5187
- Abstract
- Heme oxygenase-1 (HO-1) has anti-apoptotic and anti-inflammatory effects. In this study, the HO-1 gene was delivered into the brain using dexamethasone-conjugated polyamidoamine generation 2 (PAMAMG2-Dexa) for the treatment of ischemic stroke. PAMAM G2-Dexa formed stable complexes with plasmid DNA (pDNA). The pDNA delivery efficiency of PAMAM G2-Dexa was higher than that of polyethylenimine (PEI25k, 25 kDa), dexamethasone-conjugated PEI (PEI-Dexa), and PAMAM G2 in Neuro2A cells. Therapeutic effect of PAMAM G2-Dexa/pHO-1 complexes was evaluated in a stroke animal model. PAMAM G2-Dexa delivered pHO-1 more efficiently into the ischemic brain than PEI25k and PEI-Dexa with higher therapeutic effect. Therefore, PAMAMG2-Dexa/pHO-1 complexes may be useful for ischemic stroke gene therapy.
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Related Researcher
- Lee, Min hyung
- COLLEGE OF ENGINEERING (DEPARTMENT OF BIOENGINEERING)