Steroid plus antiviral treatment for Bell’s palsy
- Authors
- Kang, H. M.; Jung, S. Y; Byun, J. Y.; Park, M. S.; Yeo, S. G.
- Issue Date
- May-2015
- Publisher
- WILEY-BLACKWELL
- Keywords
- age; antivirals; Bell' s palsy; electroneurography; severity; steroid
- Citation
- JOURNAL OF INTERNAL MEDICINE, v.277, no.5, pp.532 - 539
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF INTERNAL MEDICINE
- Volume
- 277
- Number
- 5
- Start Page
- 532
- End Page
- 539
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/157230
- DOI
- 10.1111/joim.12288
- ISSN
- 0954-6820
- Abstract
- Objectives: The effectiveness of antiviral agents for the treatment of Bell's palsy is uncertain. We evaluated whether a steroid with an antiviral agent (S + A group) provided better recovery outcomes than a steroid alone (S group) in patients with Bell's palsy. Subjects and design: A total of 1342 patients diagnosed with Bell's palsy who visited the Kyung Hee Medical Center in Seoul, Korea, from 2002 to 2012 were included in this study. Patients in the S + A group were treated with prednisolone and antiviral agents (n = 569) and those in the S group with prednisolone alone (n = 773). Outcomes were measured using the House-Brackmann (HB) scale according to age, initial disease severity, electroneurography (ENoG) findings and underlying comorbidities. Results: The rate of recovery (HB grades I and II) with initially severe Bell's palsy (HB grades V and VI) was higher in the S + A than in the S group (P = 0.001). However, the rates of recovery were similar with initially moderate palsy (HB grades II-IV) (P = 0.502). In patients classified according to age and ENoG-determined severity of palsy, the overall recovery rate was higher in the S + A than in the S group, but the differences were not statistically significant (P > 0.05 for both). The recovery rate without diabetes mellitus (DM) and hypertension (HTN) was higher in the S + A group than in the S group (P = 0.031). But in the patients with HTN and DM, the difference in recovery rates between the S + A and S groups was not statistically significant (P = 0.805). Conclusions: Treatment with a steroid plus antiviral agent resulted in significantly higher recovery rates than steroid therapy alone in patients with initially severe Bell's palsy and without either HTN or DM, and a nonsignificant trend towards higher recovery rates in all patients with Bell's palsy in this study. Antiviral agents may therefore help in the treatment of Bell's palsy.
- Files in This Item
-
Go to Link
- Appears in
Collections - 서울 의과대학 > 서울 교육협력지원교실 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/157230)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.