Olfactory Performance and Resting State Functional Connectivity in Non-demented Drug Naive Patients with Parkinson's Disease
- Authors
- Sunwoo, Mun Kyung; Cha, Jungho; Ham, Jee Hyun; Song, Sook K.; Hong, Jin Yong; Lee, Jong-Min; Sohn, Young H.; Lee, Phil Hyu
- Issue Date
- May-2015
- Publisher
- WILEY
- Keywords
- Parkinson' s disease; resting state functional connectivity; olfaction; cognition
- Citation
- HUMAN BRAIN MAPPING, v.36, no.5, pp.1716 - 1727
- Indexed
- SCIE
SCOPUS
- Journal Title
- HUMAN BRAIN MAPPING
- Volume
- 36
- Number
- 5
- Start Page
- 1716
- End Page
- 1727
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/157313
- DOI
- 10.1002/hbm.22732
- ISSN
- 1065-9471
- Abstract
- Olfactory performance in Parkinson's disease (PD) is closely associated with subsequent cognitive decline. In the present study, we analyzed the olfaction-dependent functional connectivity with a hypothesis that olfactory performance would influence functional connectivity within key brain areas of PD. A total of 110 nondemented drug-naive patients with PD were subdivided into three groups of high score (PD-H, n=23), middle score (PD-M, n=64), and low score (PD-L, n=23) based on olfactory performance. We performed the resting-state functional connectivity with seed region of interest in the posterior cingulate cortex (PCC) and caudate. An analysis of functional connectivity revealed that PD-L patients exhibited a significant attenuation of cortical functional connectivity with the PCC in the bilateral primary sensory areas, right frontal areas, and right parietal areas compared to PD-H or PD-M patients. Meanwhile, PD-L patients exhibited a significant enhancement of striatocortical functional connectivity in the bilateral occipital areas and right frontal areas compared to PD-H or PD-M patients. In the voxel-wise correlation analysis, olfactory performance was positively associated with cortical functional connectivity with the PCC in similar areas of attenuated cortical connectivity in PD-L patients relative to PD-H patients. On the other hand, the cortical functional connectivity with the caudate was negatively correlated with olfactory performance in similar areas of increased connectivity in PD-L patients relative to PD-H patients. The present study demonstrated that resting state functional connectivity exhibits a distinctive pattern depending on olfactory performance, which might shed light on a meaningful relationship between olfactory impairment and cognitive dysfunction in PD. Hum Brain Mapp 36:1716-1727, 2015.
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