Three-month Treatment Response and Exacerbation in Chronic Obstructive Pulmonary Diseaseopen access
- Authors
- Lee, Jung Su; Rhee, Chin Kook; Yoo, Kwang Ha; Lee, Ji-Hyun; Yoon, Ho Il; Kim, Tae-Hyung; Kim, Woo Jin; Lee, JinHwa; Lim, Seong Yong; Park, Tai Sun; Lee, Jae Seung; Lee, Sei Won; Lee, Sang-Do; Oh, Yeon-Mok
- Issue Date
- Jan-2015
- Publisher
- KOREAN ACAD MEDICAL SCIENCES
- Keywords
- Pulmonary Disease; Chronic Obstructive; Forced Expiratory Volume; Disease Progression
- Citation
- JOURNAL OF KOREAN MEDICAL SCIENCE, v.30, no.1, pp.54 - 59
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- JOURNAL OF KOREAN MEDICAL SCIENCE
- Volume
- 30
- Number
- 1
- Start Page
- 54
- End Page
- 59
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/158108
- DOI
- 10.3346/jkms.2015.30.1.54
- ISSN
- 1011-8934
- Abstract
- The aim of this study was to investigate relationships between acute exacerbation and Forced Expiratory Volume 1 second (FEV1) improvement after treatment with combined long-acting beta-agonist (LABA) and inhaled corticosteroid (ICS) in patients with chronic obstructive pulmonary disease (COPD). A total of 137 COPD patients were classified as responders or nonresponders according to FEV1 improvement after 3 months of LABA/ICS treatment in fourteen referral hospitals in Korea. Exacerbation occurrence in these two subgroups was compared over a period of 1 yr. Eighty of the 137 COPD patients (58.4%) were classified as responders and 57 (41.6%) as nonresponders. Acute exacerbations occurred in 25 patients (31.3%) in the responder group and in 26 patients (45.6%) in the nonresponder group (P = 0.086). FEV1 improvement after LABA/ICS treatment was a significant prognostic factor for fewer acute exacerbations in a multivariate Cox proportional hazard model adjusted for age, sex, FEV1, smoking history, 6 min walk distance, body mass index, exacerbation history in the previous year, and dyspnea scale. Three-month treatment response to LABA/ICS might be a prognostic factor for the occurrence of acute exacerbation in COPD patients.
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