The Photoprotective Effect of S-Methylmethionine Sulfonium in Skin.open access
- Authors
- Kim, Won-Serk; Seo, Hyun Min; Kim, Wang-Kyun; Choi, Joon-Seok; Kim, Ikyon; Sung, Jong-Hyuk
- Issue Date
- 2015
- Publisher
- MDPI AG
- Keywords
- Dermal fibroblasts; Erythema; Keratinocyte progenitor cells; S-methylmethionine sulfonium; UVB protection
- Citation
- INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.16, no.8, pp.17088 - 17100
- Indexed
- SCIE
SCOPUS
- Journal Title
- INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Volume
- 16
- Number
- 8
- Start Page
- 17088
- End Page
- 17100
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/158235
- DOI
- 10.3390/ijms160817088
- ISSN
- 1661-6596
- Abstract
- S-Methylmethionine sulfonium (SMMS) was reported to have wound-healing effects; we therefore have investigated the photoprotective effect of SMMS in the present study. SMMS increased the viability of keratinocyte progenitor cells (KPCs) and human dermal fibroblasts (hDFs) following ultraviolet B (UVB) irradiation, and reduced the UVB-induced apoptosis in these cells. SMMS increased the phosphorylation of extracellular signal-regulated kinases (ERK), and the inhibitor of the mitogen-activated protein kinase pathway significantly decreased the SMMS-induced viability of KPCs and hDFs. In addition, SMMS attenuated the UVB-induced reactive oxygen species (ROS) generation in KPCs and hDFs. SMMS induced the collagen synthesis and reduced the matrix metalloproteinase-1 expression in UVB-irradiated hDFs. In animal studies, application of 5% and 10% SMMS before and after UVB-irradiation significantly decreased the UVB-induced erythema index and depletion of Langerhans cells. In summary, SMMS protects KPCs and hDFs from UVB irradiation, and reduces UVB-induced skin erythema and immune suppression. Therefore, SMMS can be used as a cosmetic raw material, and protect skin from UVB.
- Files in This Item
-
- Appears in
Collections - 서울 의과대학 > 서울 피부과학교실 > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.