Transplanted Human Amniotic Epithelial Cells Secrete Paracrine Proangiogenic Cytokines in Rat Model of Myocardial Infarction
- Authors
- Song, Yi-Sun; Joo, Hyun-Woo; Park, In-Hwa; Shen, Guang-Yin; Lee, Yonggu; Shin, Jeong Hun; Kim, Hyuck; Shin, Il-Seob; Kim, Kyung-Soo
- Issue Date
- 2015
- Publisher
- SAGE PUBLICATIONS INC
- Keywords
- Amniotic epithelial cells; Myocardial infarction (MI); Paracrine; Cytokine
- Citation
- CELL TRANSPLANTATION, v.24, no.10, pp.2055 - 2064
- Indexed
- SCIE
SCOPUS
- Journal Title
- CELL TRANSPLANTATION
- Volume
- 24
- Number
- 10
- Start Page
- 2055
- End Page
- 2064
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/158302
- DOI
- 10.3727/096368914X685609
- ISSN
- 0963-6897
- Abstract
- Human amniotic epithelial cells (h-ABCs) have been shown to differentiate into cardiomyocyte-like cells in vivo that can regenerate myocardial tissue and improve cardiac function in a rat model of myocardial infarction (MI). In this study, we investigated the paracrine factors released from h-AECs under hypoxic conditions to elucidate the possible mechanisms underlying this previously reported phenomenon of h-AEC-mediated cardiac repair. We used hypoxic cell culture conditions to simulate myocardial infarction in vitro. In comparison to normal conditions, we found that h-ABCs secreted higher levels of several cytokines, including angiogenin (ANG), epidermal growth factor (EGF), interleukin (IL)-6, and monocyte chemoattractant protein (MCP)-1. To determine whether transplanted h-ABCs express these proangiogenic cytokines in vivo, we ligated the coronary artery of rats to cause MI and injected either h-ABCs or saline into the infarcted area. We found that the infarct and border zones of rat myocardium treated with h-AECs had higher expression levels of the human-origin cytokines ANG, EGF, IL-6, and MCP-1 compared to the tissues of saline-treated rats. In conclusion, h-ABCs secreted proangiogenic cytokines in a rat model of MI, which may suggest that the paracrine effect by h-ABCs could regenerate myocardial tissue and improve cardiac function.
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