Clinical characteristics of symptomatic clostridium difficile infection in children: Conditions as infection risks and whether probiotics is effectiveopen access
- Authors
- Na, Jae Yoon; Park, Jong Mo; Lee, Kyung Suk; Kang, Jung Oak; Oh, Sung Hee; Kim, Yong Joo
- Issue Date
- Dec-2014
- Publisher
- Korean Society of Pediartic Gastroenterology, Hepatology and Nutrition
- Keywords
- Child; Clostridium difficile; Diarrhea; Probiotics
- Citation
- Pediatric Gastroenterology, Hepatology and Nutrition, v.17, no.4, pp.232 - 238
- Indexed
- SCOPUS
KCI
- Journal Title
- Pediatric Gastroenterology, Hepatology and Nutrition
- Volume
- 17
- Number
- 4
- Start Page
- 232
- End Page
- 238
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/158414
- DOI
- 10.5223/pghn.2014.17.4.232
- ISSN
- 2234-8646
- Abstract
- Purpose: This study investigated the clinical presentations of symptomatic Clostridium difficile infection (CDI) in children. Methods: We reviewed the medical records of 43 children aged < 20 years who showed either positive C. difficile culture or C. difficile toxin test results between June 2010 and April 2014. Results: Of the 43 patients (mean age 6.7 years), 22 were boys. Sixteen patients (37.2%) showed both positive C. difficile culture and toxin test results. Seventeen out of 43 children (39.5%) had preexisting gastrointestinal diseases, and 26 children had other medical conditions that were risk factors for CDI. Twenty-eight children had a history of antibiotic treatment for > 3 days, and the most frequently prescribed antibiotic was amoxicillin-clavulanate (35.7%). Twenty-eight patients were diagnosed with CDI despite taking probiotic supplements, most commonly Lactobacillus acidophilus (53.6%). The most common symptom was diarrhea (72.1%) at the time CDI was diagnosed. C. difficile was eradicated in 11 patients (25.6%) after treatment with oral metronidazole for 10-14 days, and in the two patients (4.6%) who required two courses of oral metronidazole. Sixteen patients (37.2%) showed clinical improvement without any treatment. Conclusion: This study showed the various clinical characteristics of CDI in children and that preexisting clinical conditions favored the development of CDI. In addition, CDI was found to occur in a number of patients even after probiotic prophylaxis given in conjunction with antibiotic therapy.
- Files in This Item
-
- Appears in
Collections - 서울 의과대학 > 서울 소아청소년과학교실 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/158414)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.