The effect of vitamin C intake on the risk of hyperuricemia and serum uric acid level in Korean Multi-Rural Communities Cohort
- Authors
- Bae, Jisuk; Shin, Dong Hoon; Chun, Byung-Yeol; Choi, Bo Youl; Kim, Mi Kyung; Shin, Min-Ho; Lee, Young-Hoon; Park, Pil Sook; Kim, Seong-Kyu
- Issue Date
- Dec-2014
- Publisher
- ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
- Keywords
- Vitamin C; Uric acid; Hyperuricemia
- Citation
- JOINT BONE SPINE, v.81, no.6, pp.513 - 519
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOINT BONE SPINE
- Volume
- 81
- Number
- 6
- Start Page
- 513
- End Page
- 519
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/158440
- DOI
- 10.1016/j.jbspin.2014.05.007
- ISSN
- 1297-319X
- Abstract
- Objective: The aim of this study was to determine the association between vitamin C intake and risk of hyperuricemia or serum uric acid levels in male and female subjects in the Korean Multi-Rural Communities Prospective Cohort. Methods: This cross-sectional analysis was conducted in 9400 subjects enrolled in the Korean Multi-Rural Communities Cohort Study. The risk of hyperuricemia was assessed in five quintiles (Q1 to Q5) according to dietary and total vitamin C intake using multivariate-adjusted logistic regression models. Relationships between serum uric acid levels and vitamin C intake were evaluated using linear regression analysis after adjustment for covariates. Information about dietary components was collected using validated food frequency questionnaires. Results: Dietary vitamin C intake, but not total vitamin C intake, was significantly different between hyperuricemic and non-hyperuricemic subjects in males (P = 0.01) and females (P = 0.02). The risk of hyperuricemia decreased with increased dietary vitamin C intake in male and female subjects after multivariate adjustment (P for trend = 0.002 in males and P for trend = 0.02 in females). An effect of total vitamin C intake on hyperuricemia risk was identified in females (P for trend = 0.04), but not males (P for trend = 0.06). Serum uric acid level was linearly associated with total vitamin C intake in females (beta = -0.0001, P = 0.01), but not with dietary vitamin C intake in either gender. Conclusion: This study showed that vitamin C intake might be in part responsible for hyperuricemia or serum uric acid level in the Korean Multi-Rural Communities Cohort. (C) 2014 Societe francaise de rhumatologie. Published by Elsevier Masson SAS. All rights reserved.
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