Physicochemical properties and cell permeation efficiency of l-ascorbic acid loaded nanoparticles prepared with N-trimethyl chitosan and N-triethyl chitosan
- Authors
- Jang, Keum-Il; Lee, Ji-Soo; Lee, Hyeon Gyu
- Issue Date
- Dec-2014
- Publisher
- KOREAN SOCIETY FOOD SCIENCE & TECHNOLOGY-KOSFOST
- Keywords
- ascorbic acid; trimethyl chitosan; triethyl chitosan; nanoparticle; cell permeation
- Citation
- FOOD SCIENCE AND BIOTECHNOLOGY, v.23, no.6, pp.1867 - 1874
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- FOOD SCIENCE AND BIOTECHNOLOGY
- Volume
- 23
- Number
- 6
- Start Page
- 1867
- End Page
- 1874
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/158457
- DOI
- 10.1007/s10068-014-0255-5
- ISSN
- 1226-7708
- Abstract
- The physicochemical properties and permeation efficiency of l-ascorbic acid (AA)-loaded nanoparticles (NPs) prepared using N-trimethyl chitosan (TMC) and Ntriethyl chitosan (TEC) were investigated. The sizes of AA-TMC-NPs and AA-TEC-NPs were 568 +/- 50 and 150 +/- 15 nm, respectively and both zeta potential values were slightly positively charged. The encapsulation efficiency (EE) of AA-TMC-NPs was consistently between 40 and 45%, but the EE of AA-TEC-NPs varied between 18 and 56%. The release rate increased with increased temperatures for both NPs. AA-TMC-NPs exhibited an initial burst release, while AA-TEC-NPs exhibited a controlled release, increasing rapidly after 2 h. The pH-related release pattern was similar to the temperature-related release pattern. The permeation efficiency into Caco-2 cells, in order from lowest to highest, was AA, an AA mixture with TMC, an AA mixture with TEC, AA-TMC-NPs, and AA-TEC-NPs. Both NPs showed potential to enhance the permeability of AA.
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