Expression patterns of stromal MMP-2 and tumoural MMP-2 and-9 are significant prognostic factors in invasive ductal carcinoma of the breast
- Authors
- Min, Kyueng-Whan; Kim, Dong-Hoon; Do, Sung-Im; Kim, Kyungeun; Lee, Hyun Joo; Chae, Seoung Wan; Sohn, Jin Hee; Pyo, Jung-Soo; Oh, Young-Ha; Kim, Wan-Seop; Lee, So-Young; Oh, Sukjoong; Choi, Seon Hyeong; Park, Yong Lai; Park, Chan Heun
- Issue Date
- Dec-2014
- Publisher
- WILEY
- Keywords
- MMP2; MMP9; stromal cell; invasive ductal carcinoma; breast
- Citation
- APMIS, v.122, no.12, pp.1196 - 1206
- Indexed
- SCIE
SCOPUS
- Journal Title
- APMIS
- Volume
- 122
- Number
- 12
- Start Page
- 1196
- End Page
- 1206
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/158468
- DOI
- 10.1111/apm.12285
- ISSN
- 0903-4641
- Abstract
- Matrix metalloproteinases (MMPs) are matrix-degrading enzymes that play a pivotal role in aggressive behaviours, such as rapid tumour growth, invasion, and metastasis, of several types of solid tumours. In particular, stromal MMP-2 plays important roles in the progression of malignant tumours, but most clinical studies have focused on tumoural MMP-2 and -9 expression, and not stromal MMP-2 expression. One hundred and seventy-seven cases diagnosed as invasive ductal carcinoma of the breast between 2000 and 2005 were included in this study. Expressions of tumoural MMP-2 and -9 and stromal MMP-2 were analysed by immunostaining on a tissue microarray. Subsequently, the associations between those results and various clinicopathological parameters were evaluated. Stromal MMP-2 expression correlated significantly with clinicopathological parameters such as advanced T category, larger tumour size, high histological grade, tumour necrosis, ER- and PR-negative, and HER-2-positive (all p<0.05). In univariate and multivariate analyses, overall survival was linked with stromal MMP-2 expression as well as dual expression of stromal MMP-2 and tumoural MMP-2 and -9 (all p<0.05). Stromal MMP-2 expression may play a crucial role in predicting aggressive clinical behaviour in breast cancer patients.
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