수용성 님추출물이 랫드의 간 독성에 미치는 영향open accessEffects of Aqueous Azadirachta indica Extract on Hepatotoxicity in Rats
- Other Titles
- Effects of Aqueous Azadirachta indica Extract on Hepatotoxicity in Rats
- Authors
- 박경훈; 윤현주; 한범석; 이제봉; 정미혜; 조남준; 엄애선; 백민경
- Issue Date
- Nov-2014
- Publisher
- 한국환경농학회
- Keywords
- Azadirachta indica extract; Hepatotoxicity; Oral administration; Rat
- Citation
- 한국환경농학회지, v.33, no.4, pp.395 - 402
- Indexed
- KCI
- Journal Title
- 한국환경농학회지
- Volume
- 33
- Number
- 4
- Start Page
- 395
- End Page
- 402
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/158641
- DOI
- 10.5338/KJEA.2014.33.3.395
- ISSN
- 1225-3537
- Abstract
- BACKGROUND: Azadirachta indica Extract(AIE)containing azadirachtin as active ingredient have been usedworldwide as environment-friendly organic material havingpest control properties. However, the extracts prepared withdifferent solvent and from different plant site is very diverseand have different toxicity.
METHODS AND RESULTS: In this study, the four weekrepeated oral dose toxicity test of aqueous AIE inSprague-Dawley rats was carried out to investigate the toxiceffect of liver, main toxicity target organ of AIE. The maleand female rats were divided into 4 groups, respectively;control(0 g/Kg bw), low-dose group(0.5 g/Kg bw),middle-dose(1.0 g/Kg bw) and high-dose group(2.0 g/Kgbw). As a results, relative liver weight increased withdose-dependent of AIE(p<0.05). Serum LDH in allAIE-treated groups were significantly lower than thecontrol in male rats(p<0.05). However, serum GOT andGPT were significantly increased in all male AIE-treatedgroups in male rats(p<0.05) and, in particular, increase ofserum GPT in dose-dependent manner raise the possibilityof liver damage. Even through serum GLU was increasedsignificantly in high-dose group in male rats compared tocontrol, there were no significant differences of urinary GLUamong all groups(p<0.05). In addition, histopathologicalexamination of the liver did not reveal any lesions in allAIE-treated groups.
CONCLUSION: In conclusion, 4 weeks of the repeated oraladministration of AIE 2.0 g/Kg to rats has resulted no toxicresponse in liver. Therefore, AIE was no indicated to haveany toxic effect in the SD rats, when it was orallyadministrated below the dosage 2.0 g/Kg/day for 4weeks.
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