Presence of Sarcopenia and Its Rate of Change Are Independently Associated with Long-term Mortality in Patients with Liver Cirrhosisopen access
- Authors
- Jeong, Jae Yoon; Lim, Sanghyeok; Sohn, Joo Hyun; Lee, Jae Gon; Jun, Dae Won; Kim, Yongsoo
- Issue Date
- Dec-2018
- Publisher
- KOREAN ACAD MEDICAL SCIENCES
- Keywords
- Liver Cirrhosis; Sarcopenia; Nutrition; Mortality; Prognosis
- Citation
- JOURNAL OF KOREAN MEDICAL SCIENCE, v.33, no.50
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- JOURNAL OF KOREAN MEDICAL SCIENCE
- Volume
- 33
- Number
- 50
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/15871
- DOI
- 10.3346/jkms.2018.33.e299
- ISSN
- 1011-8934
- Abstract
- Background: Sarcopenia is associated with a poor prognosis in patients with liver cirrhosis. However, it is not known whether the rate of skeletal muscle depletion is also associated with a poor prognosis. We investigated the prognostic impact of the rate of skeletal muscle depletion in patients with liver cirrhosis.
Methods: We included retrospectively all patients with liver cirrhosis who underwent both multiple computed tomography scans and hepatic venous pressure gradient (HVPG) measurements.
Results: A total of 131 patients with liver cirrhosis were enrolled. The mean age of the patients was 53.7 years and alcoholic liver disease was the most common cause (61.8%). Sixty-four patients (48.9%) were diagnosed with sarcopenia. The median changes in skeletal muscle area per year (Delta SMA/y) were -0.89%. During a median follow-up period of 46.2 months (range, 3.4-87.6), 45 patients (34.4%) died. In multivariate analyses, age, Child-Pugh score, HVPG, presence of sarcopenia and Delta SMA/y were independently associated with mortality. Cumulative mortality was significantly higher in patients with Delta SMA/y < -2.4% than those with Delta SMA/y >= -2.4% (log-rank test, P < 0.001).
Conclusion: Both the presence and rate of change of sarcopenia are independently associated with long-term mortality in patients with liver cirrhosis.
- Files in This Item
-
- Appears in
Collections - 서울 의과대학 > 서울 영상의학교실 > 1. Journal Articles
- 서울 의과대학 > 서울 내과학교실 > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.