Harmful and beneficial relationships between alcohol consumption and subclinical atherosclerosis
- Authors
- Kim, M. K.; Shin, J.; Kweon, S. -S.; Shin, D. H.; Lee, Y. -H.; Chun, B. -Y.; Choi, B. Y.
- Issue Date
- Jul-2014
- Publisher
- ELSEVIER SCI LTD
- Keywords
- Alcohol; Carotid intima-media thickness; Pulse wave velocity; Subclinical atherosclerosis; Mediator
- Citation
- NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, v.24, no.7, pp.767 - 776
- Indexed
- SCIE
SCOPUS
- Journal Title
- NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
- Volume
- 24
- Number
- 7
- Start Page
- 767
- End Page
- 776
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/159570
- DOI
- 10.1016/j.numecd.2014.02.004
- ISSN
- 0939-4753
- Abstract
- Background and aims: Arterial stiffness and increased intima-media wall thickness are two of the main predictors of cardiovascular disease (CVD). We evaluated whether brachial-ankle pulse wave velocity (baPWV) and common carotid artery intima-media wall thickness (CCA-IMT) are correlated with alcohol consumption in a cross-sectional study among Korean men and women aged 40 years and over. Methods and results: All 5539 subjects (2121 men and 3418 women) were participants in the Multi-Rural Communities cohort (MRcohort) study, a part of the Korean Genome Epidemiology Study (KoGES). The baPWV was positively correlated with alcohol consumption in men (p for trend < 0.0001). Age (middle-aged versus elderly) modified the effect of alcohol consumption on PWV. On the other hand CCA-IMT decreased with alcohol consumption in men. There was no favorable zone of alcohol consumption in terms of baPWV and CCA-IMT. Adjustment for lipid profiles substantially attenuated the relationship between alcohol consumption and CCA-IMT. There was no clear relation between alcohol consumption and baPWV/CCA-IMT in women. Conclusions: Along with a linear harmful relationship between alcohol consumption and arterial stiffness in men there may also be a beneficial relationship between alcohol consumption and carotid intima-wall thickness. The effect of alcohol on arterial stiffness may be slightly stronger in elderly men, and the effect of alcohol on CCA-IMT may be mediated by lipid factors.
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