Optimal precurarizing dose of rocuronium to decrease fasciculation and myalgia following succinylcholine administrationopen access
- Authors
- Kim, Kyu Nam; Kim, Kyo Sang; Choi, Hoon Il; Jeong, Ji Seon; Lee, Hee-Jong
- Issue Date
- Jun-2014
- Publisher
- Korean Society of Anesthesiologists
- Keywords
- Fasciculation; Myalgia; Neuromuscular blockade; Precurarization; Rocuronium; Succinylcholine
- Citation
- Korean Journal of Anesthesiology, v.66, no.6, pp.451 - 456
- Indexed
- SCOPUS
KCI
- Journal Title
- Korean Journal of Anesthesiology
- Volume
- 66
- Number
- 6
- Start Page
- 451
- End Page
- 456
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/159782
- DOI
- 10.4097/kjae.2014.66.6.451
- ISSN
- 2005-6419
- Abstract
- Background: Succinylcholine commonly produces frequent adverse effects, including muscle fasciculation and myalgia. The current study identified the optimal dose of rocuronium to prevent succinylcholine-induced fasciculation and myalgia and evaluated the influence of rocuronium on the speed of onset produced by succinylcholine. Methods: This randomized, double-blinded study was conducted in 100 patients randomly allocated into five groups of 20 patients each. Patients were randomized to receive 0.02, 0.03, 0.04, 0.05 and 0.06 mg/kg rocuronium as a precurarizing dose. Neuromuscular monitoring after each precurarizing dose was recorded from the adductor pollicis muscle using acceleromyography with train-of-four stimulation of the ulnar nerve. All patients received succinylcholine 1.5 mg/kg at 2 minutes after the precurarization, and were assessed the incidence and severity of fasciculations, while myalgia was assessed at 24 hours after surgery. Results: The incidence and severity of visible muscle fasciculation was significantly less with increasing the amount of precurarizing dose of rocuronium (P < 0.001). Those of myalgia tend to decrease according to increasing the amount of precurarizing dose of rocuronium, but there was no significance (P = 0.072). The onset time of succinylcholine was significantly longer with increasing the amount of precurarizing dose of rocuronium (P < 0.001). Conclusions: Precurarization with 0.04 mg/kg rocuronium was the optimal dose considering the reduction in the incidence and severity of fasciculation and myalgia with acceptable onset time, and the safe and effective precurarization.
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