Dietary supplementation with rice bran fermented with Lentinus edodes increases interferon-gamma activity without causing adverse effects: a randomized, double-blind, placebo-controlled, parallel-group study
DC Field | Value | Language |
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dc.contributor.author | Choi, Ji-Young | - |
dc.contributor.author | Paik, Doo-Jin | - |
dc.contributor.author | Kwon, Dae Young | - |
dc.contributor.author | Park, Yongsoon | - |
dc.date.accessioned | 2022-07-16T05:27:31Z | - |
dc.date.available | 2022-07-16T05:27:31Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2014-04 | - |
dc.identifier.issn | 1475-2891 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/160330 | - |
dc.description.abstract | Background: The purpose of this study was to investigate the hypothesis that dietary supplementation with rice bran fermented with Lentinus edodes (rice bran exo-biopolymer, RBEP), a substance known to contain arabinoxylan, enhances natural killer (NK) cell activity and modulates cytokine production in healthy adults. Methods: This study was designed in a randomized, double-blind, placebo-controlled, and parallel-group format. Eighty healthy participants with white blood cell counts of 4,000-8,000 cells/mu L were randomly assigned to take six capsules per day of either 3 g RBEP or 3 g placebo for 8 weeks. Three participants in the placebo group were excluded after initiation of the protocol; no severe adverse effects from RBEP supplementation were reported. NK cell activity of peripheral blood mononuclear cells was measured using nonradioactive cytotoxicity assay kits and serum cytokine concentrations included interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha, interleukin (IL)-2, IL-4, IL-10, and IL-12 were measured by Bio-Plex cytokine assay kit. This study was registered with the Clinical Research Information Service (KCT0000536). Results: Supplementation of RBEP significantly increased IFN-gamma production compared with the placebo group (P = 0.012). However, RBEP supplementation did not affect either NK cell activity or cytokine levels, including IL-2, IL-4, IL-10, IL-12, and TNF-alpha, compared with the placebo group. Conclusions: The data obtained in this study indicate that RBEP supplementation increases IFN-gamma secretion without causing significant adverse effects, and thus may be beneficial to healthy individuals. This new rice bran-derived product may therefore be potentially useful to include in the formulation of solid and liquid foods designed for treatment and prevention of pathological states associated with defective immune responses. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | BMC | - |
dc.title | Dietary supplementation with rice bran fermented with Lentinus edodes increases interferon-gamma activity without causing adverse effects: a randomized, double-blind, placebo-controlled, parallel-group study | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Paik, Doo-Jin | - |
dc.contributor.affiliatedAuthor | Park, Yongsoon | - |
dc.identifier.doi | 10.1186/1475-2891-13-35 | - |
dc.identifier.scopusid | 2-s2.0-84899901302 | - |
dc.identifier.wosid | 000209598500001 | - |
dc.identifier.bibliographicCitation | NUTRITION JOURNAL, v.13, no.1, pp.1 - 7 | - |
dc.relation.isPartOf | NUTRITION JOURNAL | - |
dc.citation.title | NUTRITION JOURNAL | - |
dc.citation.volume | 13 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 7 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.subject.keywordPlus | KILLER-CELL ACTIVITY | - |
dc.subject.keywordPlus | MODIFIED ARABINOXYLAN | - |
dc.subject.keywordPlus | NATURAL CYTOTOXICITY | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | POLYSACCHARIDE | - |
dc.subject.keywordPlus | MGN-3 | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | ENHANCEMENT | - |
dc.subject.keywordPlus | ANTITUMOR | - |
dc.subject.keywordPlus | COUNT | - |
dc.subject.keywordAuthor | Cytokines | - |
dc.subject.keywordAuthor | Fermented rice bran | - |
dc.subject.keywordAuthor | Immune response | - |
dc.subject.keywordAuthor | Natural killer cell | - |
dc.subject.keywordAuthor | Randomized clinical study | - |
dc.identifier.url | https://nutritionj.biomedcentral.com/articles/10.1186/1475-2891-13-35 | - |
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