Dietary supplementation with rice bran fermented with Lentinus edodes increases interferon-gamma activity without causing adverse effects: a randomized, double-blind, placebo-controlled, parallel-group studyopen access
- Authors
- Choi, Ji-Young; Paik, Doo-Jin; Kwon, Dae Young; Park, Yongsoon
- Issue Date
- Apr-2014
- Publisher
- BMC
- Keywords
- Cytokines; Fermented rice bran; Immune response; Natural killer cell; Randomized clinical study
- Citation
- NUTRITION JOURNAL, v.13, no.1, pp.1 - 7
- Indexed
- SCIE
SCOPUS
- Journal Title
- NUTRITION JOURNAL
- Volume
- 13
- Number
- 1
- Start Page
- 1
- End Page
- 7
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/160330
- DOI
- 10.1186/1475-2891-13-35
- ISSN
- 1475-2891
- Abstract
- Background: The purpose of this study was to investigate the hypothesis that dietary supplementation with rice bran fermented with Lentinus edodes (rice bran exo-biopolymer, RBEP), a substance known to contain arabinoxylan, enhances natural killer (NK) cell activity and modulates cytokine production in healthy adults. Methods: This study was designed in a randomized, double-blind, placebo-controlled, and parallel-group format. Eighty healthy participants with white blood cell counts of 4,000-8,000 cells/mu L were randomly assigned to take six capsules per day of either 3 g RBEP or 3 g placebo for 8 weeks. Three participants in the placebo group were excluded after initiation of the protocol; no severe adverse effects from RBEP supplementation were reported. NK cell activity of peripheral blood mononuclear cells was measured using nonradioactive cytotoxicity assay kits and serum cytokine concentrations included interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha, interleukin (IL)-2, IL-4, IL-10, and IL-12 were measured by Bio-Plex cytokine assay kit. This study was registered with the Clinical Research Information Service (KCT0000536). Results: Supplementation of RBEP significantly increased IFN-gamma production compared with the placebo group (P = 0.012). However, RBEP supplementation did not affect either NK cell activity or cytokine levels, including IL-2, IL-4, IL-10, IL-12, and TNF-alpha, compared with the placebo group. Conclusions: The data obtained in this study indicate that RBEP supplementation increases IFN-gamma secretion without causing significant adverse effects, and thus may be beneficial to healthy individuals. This new rice bran-derived product may therefore be potentially useful to include in the formulation of solid and liquid foods designed for treatment and prevention of pathological states associated with defective immune responses.
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