Clinical outcomes of transjugular intrahepatic portosystemic shunt for portal hypertension: Korean multicenter real-practice dataopen access
- Authors
- 김형기; 김윤준; 정우진; 김순선; 심재준; 최문석; 김도영; 전대원; 엄순호; 박성재; 우현영; 정영걸; 백순구; 김문영; 박수영; 이재명; 김영석
- Issue Date
- Mar-2014
- Publisher
- 대한간학회
- Keywords
- Liver cirrhosis; Transjugular intrahepatic portosystemic shunt; Portal hypertension
- Citation
- Clinical and Molecular Hepatology, v.20, no.1, pp.18 - 27
- Indexed
- SCOPUS
KCI
- Journal Title
- Clinical and Molecular Hepatology
- Volume
- 20
- Number
- 1
- Start Page
- 18
- End Page
- 27
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/160461
- DOI
- 10.3350/cmh.2014.20.1.18
- ISSN
- 2287-2728
- Abstract
- Background/Aims: This retrospective study assessed the clinical outcome of a transjugular intrahepaticportosystemic shunt (TIPS) procedure for managing portal hypertension in Koreans with liver cirrhosis.
Methods: Between January 2003 and July 2013, 230 patients received a TIPS in 13 university-based hospitals.
Results: Of the 229 (99.6%) patients who successfully underwent TIPS placement, 142 received a TIPS for varicealbleeding, 84 for refractory ascites, and 3 for other indications. The follow-up period was 24.9±30.2 months (mean±SD),74.7% of the stents were covered, and the primary patency rate at the 1-year follow-up was 78.7%. Hemorrhageoccurred in 30 (21.1%) patients during follow-up; of these, 28 (93.3%) cases of rebleeding were associated with stentdysfunction. Fifty-four (23.6%) patients developed new hepatic encephalopathy, and most of these patients weresuccessfully managed conservatively. The cumulative survival rates at 1, 6, 12, and 24 months were 87.5%, 75.0%,66.8%, and 57.5%, respectively. A high Model for End-Stage Liver Disease (MELD) score was significantly associatedwith the risk of death within the first month after receiving a TIPS (P=0.018). Old age (P<0.001), indication for a TIPS(ascites vs. bleeding, P=0.005), low serum albumin (P<0.001), and high MELD score (P=0.006) were associated withoverall mortality.
Conclusions: A high MELD score was found to be significantly associated with early and overall mortality rate in TIPSpatients. Determining the appropriate indication is warranted to improve survival in these patients.
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