Unrelated donor cord blood transplantation for non-malignant disorders in children and adolescents
- Authors
- Park, Meerim; Lee, Young Ho; Kang, Hae-Ryong; Lee, Ji Won; Kang, Hyoung Jin; Park, Kyung Duk; Shin, Hee Young; Ahn, Hyo Seop; Baek, Hee Jo; Kook, Hoon; Hwang, Tai Ju; Lee, Jae Wook; Chung, Nack-Gyun; Cho, Bin; Kim, Hack-Ki; Lee, Soo Hyun; Yoo, Keon Hee; Sung, Ki Woong; Koo, Hong Hoe; Koh, Kyung Nam; Im, Ho Joon; Seo, Jong Jin; Park, Jun Eun; Lim, Yeon Jung; Lyu, Chuhl Joo; Lee, Jae Min; Hah, Jeong Ok
- Issue Date
- Mar-2014
- Publisher
- WILEY
- Keywords
- unrelated cord blood transplantation; non-malignant disease; children; adolescents
- Citation
- PEDIATRIC TRANSPLANTATION, v.18, no.2, pp.221 - 229
- Indexed
- SCIE
SCOPUS
- Journal Title
- PEDIATRIC TRANSPLANTATION
- Volume
- 18
- Number
- 2
- Start Page
- 221
- End Page
- 229
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/160494
- DOI
- 10.1111/petr.12213
- ISSN
- 1397-3142
- Abstract
- This study analyzes the data reported to the Korean Cord Blood Registry between 1994 and 2008, involving children and adolescents with non-malignant diseases. Sixty-five patients were evaluated in this study: SAA (n=24), iBMFS, (n=16), and primary immune deficiency/inherited metabolic disorder (n=25). The CI of neutrophil recovery was 73.3% on day 42. By day 100, the CI of acute grade II-IV graft-versus-host disease was 32.3%. At a median follow-up of 71months, five-yr OS was 50.7%. The survival rate (37.5%) and CI of neutrophil engraftment (37.5%) were lowest in patients with iBMFS. Deaths were mainly due to infection, pulmonary complications, and hemorrhage. In a multivariate analysis, the presence of >3.91x10(5)/kg of infused CD34+ cells was the only factor consistently identified as significantly associated with neutrophil engraftment (p=0.04) and OS (p=0.03). UCBT using optimal cell doses appears to be a feasible therapy for non-malignant diseases in children and adolescents for whom there is no appropriate HLA-matched related donor. Strategies to reduce transplant-related toxicities would improve the outcomes of UCBT in non-malignant diseases.
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