Mast cell number, substance P and vasoactive intestinal peptide in irritable bowel syndrome with diarrhea
- Authors
- Sohnn, Won; Lee, Oh Young; Lee, Sang Pyo; Lee, Kang Nyeong; Jun, Dae Won; Lee, Hang Lak; Yoon, Byung Chul; Choi, Ho Soon; Sim, Jongmin; Jang, Ki-Seok
- Issue Date
- Jan-2014
- Publisher
- TAYLOR & FRANCIS LTD
- Keywords
- irritable bowel syndrome; mast cell; substance P; vasoactive intestinal peptide
- Citation
- SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, v.49, no.1, pp.43 - 51
- Indexed
- SCIE
SCOPUS
- Journal Title
- SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
- Volume
- 49
- Number
- 1
- Start Page
- 43
- End Page
- 51
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/160910
- DOI
- 10.3109/00365521.2013.857712
- ISSN
- 0036-5521
- Abstract
- Background. Recent studies have shown that mast cells play an important role in irritable bowel syndrome (IBS). We investigated the relationship between mast cells and the gut hormones substance P and vasoactive intestinal peptide (VIP) in irritable bowel syndrome with diarrhea (IBS-D). Methods. Colonoscopic biopsies were performed on the rectal mucosa of 43 subjects (IBS-D patients: 22, healthy volunteers: 21) diagnosed according to the Rome III criteria. Mast cells, and substance P & VIP were evaluated by quantitative immunohistology and image analysis. Mast cells were counted as tryptase-positive cells in the lamina propria, and substance P and VIP levels were expressed as percentages of total areas of staining. Results. Mast cell counts were higher in IBS-D patients than healthy volunteers (9.6 +/- 3.3 vs. 5.7 +/- 2.5/high power field (HPF), p < 0.01). Substance P was also elevated (0.11 +/- 0.08% vs. 0.03 +/- 0.02 %, p < 0.01) while VIP was only high in women with IBS-D. Mast cell counts were positively correlated with levels of substance P & VIP in women but not men (women: r = 0.625, p < 0.01 for substance P and r = 0.651, p < 0.01 for VIP). However, mast cell counts were not correlated with IBS symptoms including abdominal pain. Conclusion. Mast cells are activated leading to the raised levels of substance P & VIP in IBS-D patients. However, the correlation between mast cells and levels of substance P & VIP differs according to gender.
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