혈액투석 환자의 단백질 섭취량에 따른 혈중 albumin과 hs-CRP 농도의 비교 연구open accessComparative study of serum levels of albumin and hs-CRP in hemodialysis patients according to protein intake levels
- Other Titles
- Comparative study of serum levels of albumin and hs-CRP in hemodialysis patients according to protein intake levels
- Authors
- 이예지; 이연주; 오일환; 이창화; 이상선
- Issue Date
- Dec-2013
- Publisher
- Korean Nutrition Society
- Keywords
- Hemodialysis patients; Hs-CRP; MIA syndrome; Protein intake; Serum albumin
- Citation
- Journal of Nutrition and Health, v.46, no.6, pp.521 - 530
- Indexed
- SCOPUS
KCI
- Journal Title
- Journal of Nutrition and Health
- Volume
- 46
- Number
- 6
- Start Page
- 521
- End Page
- 530
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/161357
- DOI
- 10.4163/jnh.2013.46.6.521
- ISSN
- 2288-3886
- Abstract
- Protein-energy malnutrition, PEM, and increased hs-CRP level are considered to be associated with increased risk of cardiovascular disease (CVD) in hemodialysis (HD) patients. This is commonly referred to as the vicious circle of malnutrition-infammation-atherosclerosis cardiovascular disease (MIA syndrome) in chronic kidney disease (CKD). Low protein intake can decrease the serum level of albumin and increase infammational markers; further, both low serum albumin and high hs-CRP are independent risk factors for all-cause mortality in HD patients. The aim of this study is comparing the serum levels of albumin and hs-CRP in HD patients according to the protein intake levels. The total number of subjects was 60 hemodialysis patients; they were grouped by dietary protein intake: low protein intake group (LPI, protein intake < 1.0 g/kg IBW, 11 men and 19 women) and adequate protein intake group (API, protein intake > 1.0 g/kg IBW, 12 men and 18 women). Blood biochemical parameters, nutrient intake, and dietary behaviors were compared between the LPI and API groups. The LPI group showed a signifcantly lower serum level of albumin and higher serum level of hs-CRP than the API group (p < 0.05). The LPI group showed a signifcantly lower intake of most nutrients than the API group (p < 0.05). Index of Nutritional Quality of most nutrients of the LPI and API groups were lower than 1.0. Dietary protein intake was positively correlated with the serum level of albumin (r = 0.306, p < 0.05) and negatively correlated with the serum level of hs-CRP (r = -0.435, p < 0.01). The serum level of hs-CRP was negatively correlated with that of albumin (r = -0.393, p < 0.01). According to these result, serum albumin and hs-CRP in HD patients were infuenced by the protein intake levels. To prevent MIA syndrome, it is necessary to improve nutritional status, especially in protein and energy.
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