Superoxide Anion Production by Human Neutrophils Activated by Trichomonas vaginalisopen access
- Authors
- Song, Hyun-Ouk; Ryu, Jae-Sook
- Issue Date
- Aug-2013
- Publisher
- KOREAN SOC PARASITOLOGY, SEOUL NATL UNIV COLL MEDI
- Keywords
- Trichomonas vaginalis; neutrophil; superoxide anion; myeloperoxidase; growth inhibition
- Citation
- KOREAN JOURNAL OF PARASITOLOGY, v.51, no.4, pp.479 - 484
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- KOREAN JOURNAL OF PARASITOLOGY
- Volume
- 51
- Number
- 4
- Start Page
- 479
- End Page
- 484
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/162263
- DOI
- 10.3347/kjp.2013.51.4.479
- ISSN
- 0023-4001
- Abstract
- Neutrophils are the predominant inflammatory cells found in vaginal discharges of patients infected with Trichomonas vaginalis. In this study, we examined superoxide anion (O-2(center dot-)) production by neutrophils activated by T vaginalis. Human neutrophils produced superoxide anions when stimulated with either a lysate of T vaginalis, its membrane component (MC), or excretory-secretory product (ESP). To assess the role of trichomonad protease in production of superoxide anions by neutrophils, T vaginalis lysate, ESP, and MC were each pretreated with a protease inhibitor cocktail before incubation with neutrophils. Superoxide anion production was significantly decreased by this treatment. Trichomonad growth was inhibited by preincubation with supernatants of neutrophils incubated for 3 hr with T vaginalis lysate. Furthermore, myeloperoxidase (MPO) production by neutrophils was stimulated by live trichomonads. These results indicate that the production of superoxide anions and MPO by neutrophils stimulated with T vaginalis may be a part of defense mechanisms of neutrophils in trichomoniasis.
- Files in This Item
-
- Appears in
Collections - 서울 의과대학 > 서울 환경의생물학교실 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/162263)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.