Bio-inspired catechol conjugation converts water-insoluble chitosan into a highly water-soluble, adhesive chitosan derivative for hydrogels and LbL assembly
- Authors
- Kim, Kyuri; Ryu, Ji Hyun; Lee, Dong Yun; Lee, Haeshin
- Issue Date
- Jul-2013
- Publisher
- ROYAL SOC CHEMISTRY
- Citation
- BIOMATERIALS SCIENCE, v.1, no.7, pp.783 - 790
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOMATERIALS SCIENCE
- Volume
- 1
- Number
- 7
- Start Page
- 783
- End Page
- 790
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/162370
- DOI
- 10.1039/c3bm00004d
- ISSN
- 2047-4830
- Abstract
- This report describes a simple method to prepare water-soluble chitosan derivative by conjugation of an enediol group, catechol. Chitosan functionalized with a catechol-containing compound, 3,4-dihydroxy-hydrocinnamic acid, by a carbodiimide coupling method resulted in chitosan-catechol conjugates. This one-step chemical modification of high-molecular-weight chitosan (approximately 100 kDa) dramatically increased the water solubility of the chitosan derivative to 60 mg mL(-1) at pH 7.0. The degree of catechol conjugation was found critical in determining the solubility. The chitosan-catechol conjugates are not only water-soluble but are adhesive, due to the intrinsic adhesive properties of catechol. Also, the water-soluble chitosan derivative allows one to directly form chitosan hydrogel in neutral buffer solutions. The utility of both the water solubility and the adhesive property of the chitosan-catechol was demonstrated by the effective layer-by-layer assembly on substrates. The water-soluble chitosan-catechol is expected to be useful in many areas of surface functionalization, drug delivery, tissue engineering, and tissue adhesives.
- Files in This Item
-
Go to Link
- Appears in
Collections - 서울 공과대학 > 서울 생명공학과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/162370)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.