Establishing an in vivo p48ZnF bioluminescence mouse brain imaging model
- Authors
- Heese, Klaus
- Issue Date
- May-2013
- Publisher
- ELSEVIER IRELAND LTD
- Keywords
- p48ZnF; Dfrp1; Drg1; Zinc finger; Gene transcription
- Citation
- NEUROSCIENCE LETTERS, v.542, pp.97 - 101
- Indexed
- SCIE
SCOPUS
- Journal Title
- NEUROSCIENCE LETTERS
- Volume
- 542
- Start Page
- 97
- End Page
- 101
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/162913
- DOI
- 10.1016/j.neulet.2013.02.044
- ISSN
- 0304-3940
- Abstract
- p48ZnF is a C3H1 zinc finger domain-containing protein that is involved in the control of gene transcription and translation. In the present study a novel transgenic p48ZnF mouse model is described that is useful for in vivo brain imaging using luciferase as bioluminescence-mediating reporter gene. Yeast two-hybrid screening and western blot analyses revealed Drg1 (developmentally regulated GTP binding protein 1) and Pcbp1 (poly (rC)-binding protein 1) as p48ZnF-associated proteins. Interestingly, p48ZnF' cellular location of action depends on the cell's differentiation status: nuclear in proliferating cells and cytoplasmic in differentiated neurons.
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