Rheumatoid Fibroblast-like Synoviocytes Downregulate Foxp3 Expression by Regulatory T Cells Via GITRL/GITR Interactionopen access
- Authors
- Kim, Sung Hoon; Youn, Jeehee
- Issue Date
- Oct-2012
- Publisher
- 대한면역학회
- Keywords
- Autoimmune arthritis; Regulatory T cells; Fibroblast-like synoviocytes; Foxp3
- Citation
- Immune Network, v.12, no.5, pp.217 - 221
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- Immune Network
- Volume
- 12
- Number
- 5
- Start Page
- 217
- End Page
- 221
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/164495
- DOI
- 10.4110/in.2012.12.5.217
- ISSN
- 1598-2629
- Abstract
- Fibroblast-like synoviocytes (FLS) colocalize with leukocyte infiltrates in rheumatoid synovia. Proinflammatory leukocytes are known to amplify inflammation by signaling to FLS,but crosstalk between FLS and regulatory T cells (Tregs) remains uncharacterized. To address this possibility, we cocultured FLS lines derived from arthritic mice with Tregs. FLS that expressed the ligand for glucocorticoid-induced TNF receptor family-related gene (GITR) decreased expression of Foxp3 and GITR in Tregs in a contact-dependent manner. This effect was abolished by blocking antibody to GITR. On the other hand, the Tregs caused the FLS to increase IL-6production. These results demonstrate that inflamed FLS license Tregs to downregulate Foxp3 expression via the GITRL/GITR interaction while the Tregs induce the FLS to increase their production of IL-6. Our findings suggest that the interaction between FLS and Tregs dampens the anti-inflammatory activity of Tregs and amplifies the proinflammatory activity of FLS, thereby exacerbating inflammatory arthritis.
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