Omega-3 fatty acid supplementation increases 1,25-dihydroxyvitamin D and fetuin-A levels in dialysis patients
DC Field | Value | Language |
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dc.contributor.author | An, Won Suk | - |
dc.contributor.author | Lee, Su Mi | - |
dc.contributor.author | Son, Young Ki | - |
dc.contributor.author | Kim, Seong Eun | - |
dc.contributor.author | Kim, Ki Hyun | - |
dc.contributor.author | Han, Jin Yeong | - |
dc.contributor.author | Bae, Hae Rahn | - |
dc.contributor.author | Rha, Seo Hee | - |
dc.contributor.author | Park, Yongsoon | - |
dc.date.accessioned | 2022-07-16T14:40:06Z | - |
dc.date.available | 2022-07-16T14:40:06Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2012-07 | - |
dc.identifier.issn | 0271-5317 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/165181 | - |
dc.description.abstract | Vitamin D deficiency, low levels of fetuin-A, and fibroblast growth factor 23 (FGF-23) are related to vascular calcification, which is associated with cardiovascular disease. We hypothesized that omega-3 fatty acid (FA), which has cardioprotective properties, modifies vitamin D status, fetuin-A, and FGF-23 levels in dialysis patients. In a randomized, open-label, controlled study, a total of 47 patients treated with dialysis for at least 1 year were randomized to treatment for 6 months with omega-3 FAs (Omacor, 3 g/d; Pronova, Sandefjord, Norway) or a control group. Levels of fetuin-A and FGF-23 were measured by enzyme-linked immunoassay, 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D were measured by radioimmunoassay. The mean age of the enrolled patients was 57.4 +/- 10.4 years, and mean dialysis duration was 46.5 +/- 28.1 months. Twenty-seven hemodialysis patients and 16 peritoneal dialysis patients finished this trial. After 6 months, the levels of 1,25-dihydroxyvitamin D and fetuin-A were significantly increased in the group taking the omega-3 FA supplement compared with baseline. Levels of calcium, phosphorous, parathyroid hormone, 25-hydroxyvitamin D, FGF-23, and lipid profiles were not significantly changed in the omega-3 FA-supplemented group after 6 months compared with baseline. The erythrocyte membrane contents of eicosapentaenoic acid and docosahexaenoic acid were significantly increased, and oleic acid content was significantly decreased in the omega-3 FA-supplemented group after 6 months compared with baseline. Regarding vascular calcification and cardiovascular disease, omega-3 FA supplementation may have a clinical benefit caused by activating vitamin D, increasing fetuin-A levels, and modifying erythrocyte membrane FA contents in dialysis patients. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.title | Omega-3 fatty acid supplementation increases 1,25-dihydroxyvitamin D and fetuin-A levels in dialysis patients | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Yongsoon | - |
dc.identifier.doi | 10.1016/j.nutres.2012.06.005 | - |
dc.identifier.scopusid | 2-s2.0-84865195959 | - |
dc.identifier.wosid | 000307917100004 | - |
dc.identifier.bibliographicCitation | NUTRITION RESEARCH, v.32, no.7, pp.495 - 502 | - |
dc.relation.isPartOf | NUTRITION RESEARCH | - |
dc.citation.title | NUTRITION RESEARCH | - |
dc.citation.volume | 32 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 495 | - |
dc.citation.endPage | 502 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.subject.keywordPlus | N-3 FATTY-ACIDS | - |
dc.subject.keywordPlus | PLACEBO-CONTROLLED INTERVENTION | - |
dc.subject.keywordPlus | 25-HYDROXYVITAMIN D LEVELS | - |
dc.subject.keywordPlus | CORONARY-ARTERY DISEASE | - |
dc.subject.keywordPlus | EXTRA-RENAL PRODUCTION | - |
dc.subject.keywordPlus | VITAMIN-D | - |
dc.subject.keywordPlus | HEMODIALYSIS-PATIENTS | - |
dc.subject.keywordPlus | PERITONEAL-DIALYSIS | - |
dc.subject.keywordPlus | CALCIFICATION | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordAuthor | 1,25-dihydroxyvitamin D | - |
dc.subject.keywordAuthor | Dialysis | - |
dc.subject.keywordAuthor | Fetuin-A | - |
dc.subject.keywordAuthor | Fibroblast growth factor 23 | - |
dc.subject.keywordAuthor | Omega-3 fatty acid | - |
dc.subject.keywordAuthor | Human | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0271531712001224?via%3Dihub | - |
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