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Omega-3 fatty acid supplementation increases 1,25-dihydroxyvitamin D and fetuin-A levels in dialysis patients

Authors
An, Won SukLee, Su MiSon, Young KiKim, Seong EunKim, Ki HyunHan, Jin YeongBae, Hae RahnRha, Seo HeePark, Yongsoon
Issue Date
Jul-2012
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Keywords
1,25-dihydroxyvitamin D; Dialysis; Fetuin-A; Fibroblast growth factor 23; Omega-3 fatty acid; Human
Citation
NUTRITION RESEARCH, v.32, no.7, pp.495 - 502
Indexed
SCIE
SCOPUS
Journal Title
NUTRITION RESEARCH
Volume
32
Number
7
Start Page
495
End Page
502
URI
https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/165181
DOI
10.1016/j.nutres.2012.06.005
ISSN
0271-5317
Abstract
Vitamin D deficiency, low levels of fetuin-A, and fibroblast growth factor 23 (FGF-23) are related to vascular calcification, which is associated with cardiovascular disease. We hypothesized that omega-3 fatty acid (FA), which has cardioprotective properties, modifies vitamin D status, fetuin-A, and FGF-23 levels in dialysis patients. In a randomized, open-label, controlled study, a total of 47 patients treated with dialysis for at least 1 year were randomized to treatment for 6 months with omega-3 FAs (Omacor, 3 g/d; Pronova, Sandefjord, Norway) or a control group. Levels of fetuin-A and FGF-23 were measured by enzyme-linked immunoassay, 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D were measured by radioimmunoassay. The mean age of the enrolled patients was 57.4 +/- 10.4 years, and mean dialysis duration was 46.5 +/- 28.1 months. Twenty-seven hemodialysis patients and 16 peritoneal dialysis patients finished this trial. After 6 months, the levels of 1,25-dihydroxyvitamin D and fetuin-A were significantly increased in the group taking the omega-3 FA supplement compared with baseline. Levels of calcium, phosphorous, parathyroid hormone, 25-hydroxyvitamin D, FGF-23, and lipid profiles were not significantly changed in the omega-3 FA-supplemented group after 6 months compared with baseline. The erythrocyte membrane contents of eicosapentaenoic acid and docosahexaenoic acid were significantly increased, and oleic acid content was significantly decreased in the omega-3 FA-supplemented group after 6 months compared with baseline. Regarding vascular calcification and cardiovascular disease, omega-3 FA supplementation may have a clinical benefit caused by activating vitamin D, increasing fetuin-A levels, and modifying erythrocyte membrane FA contents in dialysis patients.
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